健康志愿者口服青蒿琥酯片剂的生物利用度  

Pharmacokinetics of Artesunate in Chinese Volunteers and the Bioavailability of Artesunate Tablet

作　　者：林炳鎏[1] 陈芝喜[1] 贾可亮[1] 李志强[1] 陈津岩[1] 符林春 李国桥 

机构地区：[1]广州中医学院核医学研究室 [2]三亚热带医学研究所

出　　处：《广州中医学院学报》1990年第3期163-166,共4页

摘　　要：本文报道用放射免疫测定法研究口服青蒿琥酯片剂的生物利用度,结果为静脉注射青蒿琥酯后的血药时程为二房室模型,T1/2β为33.96±4.73分钟;口服青蒿琥酯片剂后的血药时程为一房室模型,其达峰时间为53.07±20.58分钟,峰浓度为1.94±1.05mg/L(1.94±1.05μg/ml),T1/2k为41.35±17.89分钟,绝对生物利用度为40.39±14.99％。结果提示口服青蒿琥酯片剂后,在人体内的吸收速度较快,而吸收程度较差。The pharmacokinetics and the bioavailability of Artesunate were investigated in the present study by using radioimmunoassay to measure serum concentration periodically for 9 hrs (i.v.) and 15 hrs (p.o.) in the healthy subjects. The concentration time data were analysed with the MCPKP-automatic pharmacokinetic program on an IBM microcom- puter. The result showed that the concentration time course after i.v. administration (120mg) were fitted to a linear two-compartment open model and the pharmacokinetics after p.o. Artesunate tablet (120mg) was described by one compartment open model. The maximum serum concentration (Cmax) and the time to maximum serum con- centration (Tmax) of oral administration are 1.94±1.05(μg/ml) and 53±20 (rain) respec- tively; T(1/2)k is 41.35±17.89 (min) and the absolute bioavailability is 40.39±14.99%. The result suggested that the Artesunate tablet is absorbed rapidly but the bioavailability is low.

关 键 词：青蒿素 药代动力学 抗疟药 

分 类 号：R285.6[医药卫生—中药学]