分枝杆菌多糖治疗支气管哮喘的临床研究  

A Clinic Study of Mycobacterial Polysaccharides on Treatment of Bronchial Asthma

作　　者：陆吉贤[1] 王健军[1] 刘复强[1] 叶志明[1] 张进友[1] 王津津[1] 陈海伦[2] 陈仁[2] 

机构地区：[1]首都医科大学附属北京同仁医院内科 [2]首都医科大学微生物学教研室

出　　处：《首都医科大学学报》1997年第1期37-40,共4页Journal of Capital Medical University

摘　　要：对５２例支气管哮喘发作期患者进行了外周血Ｔ细胞亚群、ＩｇＧ４、ＩｇＥ、ｓＩＬ－２Ｒ、ＡＣＴＨ及皮质醇的测定。结果显示哮喘发作期ＩｇＧ４、ＩｇＥ、ｓＩＬ－２Ｒ及ＡＣＴＨ均显著升高，提示哮喘患者存在细胞免疫及内分泌功能的异常。将分枝杆菌多糖（ＭＰＳ）用于３２例哮喘患者的治疗，结果与２０例常规治疗组比较，ＭＰＳ组ＣＤ４＋／ＣＤ８＋比值明显升高，ＩｇＧ４和ｓＩＬ－２Ｒ显著下降，而皮质醇和ＡＣＴＨ无明显变化。cell subgroup,IgG 4 ,IgE,sIL 2R,ACTH and cortisol in 52 patients peripheral blood with bronchial asthma onset phase,as well as 50 controls were measured.The levels of IgG 4 ,IgE,sIL 2R and ACTH in asthma patients were significantly higher compared to those of controls.The results suggest abnormality of cell immunity and endocrinic function in asthma onset phase.52 patients were divided into 2 groups,32 were treated with MPS,20 with regular therapy.The values of CD 4 +/CD 8 + in 32 patients after treatment with MPS greatly increased and the levels of IgG 4 ,sIL 2R decreased,but ACTH,cortisol did not change.

关 键 词：哮喘 分枝杆菌多糖 

分 类 号：R562.250.5[医药卫生—呼吸系统]