肾上腺紧张素在原发性高血压患者中变化的临床意义  

The Clinical Significance of Plasma Adrenotensin Level in Essential Hypertension

作　　者：石湘芸[1] 张照馥[1] 赵云涛[1] 高连茹[1] 田慧生[1] 费宇行[1] 丁殿勋[1] 唐朝枢[1,2] 周兰[1,2] 田青[1,3] 张肇康[1,3] 

机构地区：[1]解放军海军总医院,100037 [2]北京医科大学心血管基础研究所 [3]Phoenix Pharmaceuticals U.S.A

出　　处：《江苏医药》1997年第4期233-235,共3页Jiangsu Medical Journal

摘　　要：用特异性放免法测定45例原发性高血压（EH）患者血浆肾上腺紧张素［ADM（153－185）］的水平。结果示EH组低于肾实质性高血压组，亦明显低于对照组；EHⅠ、Ⅱ、Ⅲ期的血浆ADM（153－185）水平组间比较有显著或非常显著差异（P＜0．05～0．001）；经降压治疗4周的30例EH患者血浆ADM（153－185）水平明显上升。提示ADM在调节血管舒缩中可能起一定作用。Plasma adrenotensin [Adrenomedullin, ADM (153-185)] level was measured by specific radioim-munoassay in 45 patinents with essential hypertension (EH). The results showed that plasma ADM(l53-185) lev-el of EH group was lower than that of renal parenchymal hypertension group (P<0.01) and control group (P<o.001), The level of plasma ADM(153-185)had significant difference among I, and stage of EH while com-pared with each other (P<0. 05~0.0001). ADM (153-185) level was markedly increased (P<0.001) after 4 weeks' follow up in 3o patients who received antihypertensive treatment- These data suggested that changes of plasma ADM(153-185) may play an important role in the regulation of vasomotortonicity.

关 键 词：肾上腺紧张素 原发性 高血压 

分 类 号：R544.102[医药卫生—心血管疾病]