全反式维甲酸对家兔动脉平滑肌细胞生长的影响  

Effects of All Trans Retinoic Acid on Proliferation of Rabbit Vascular Smooth Muscle cells

作　　者：余晨光[1] 章鲁[2] 顾培坤[1] 金正均[1] 

机构地区：[1]上海第二医科大学药理教研室,200025 [2]上海第二医科大学计算机室

出　　处：《上海第二医科大学学报》1997年第2期99-101,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：应用家兔主动脉平滑肌细胞培养，3H－TdR掺入和细胞计数的方法，观察到全反式维甲酸明显抑制培养的血管平滑肌细胞增殖和血小板激活因子诱导的血管平滑肌细胞增殖作用。By means of techniques of cell culture, 3H-thymidine incorporation and cell count, it was demonstrated that all trans retinoic acid(ATRA) inhibited significantly serum and platelet activating factor-stimulated proliferation in cultured rabbit vascular smooth muscle cells in a dose dependent manner.

关 键 词：全反式维甲酸 血管平滑肌 动脉粥样硬化 

分 类 号：R543.505[医药卫生—心血管疾病]