^(31)P磁共振频谱成像研究及应用的进展  

Research on ^(31)P magnetic resonance spectroscopic imaging and its applications

作　　者：陈耀文[1] 沈智威[2] 黄静霞[3] 王慧[2] 林月娟[1] 吴仁华[2] 

机构地区：[1]汕头大学中心实验室,汕头515063 [2]汕头大学医学院第二附属医院,汕头515041 [3]汕头大学广东省数字图像处理重点实验室,汕头515063

出　　处：《中国体视学与图像分析》2007年第3期226-231,共6页Chinese Journal of Stereology and Image Analysis

基　　金：国家自然科学基金资助项目(No.30570480);汕头大学研究与发展基金资助(No.L00015)

摘　　要：磷是能量代谢的重要要素,人体内许多化合物都含有磷。磁共振频谱成像(MRSI)是将磁共振成像(MR I)提供的空间信息和MRS提供的频谱信息有机结合起来的一种成像技术,是目前无创伤研究活体组织器官代谢、生化变化及化合物定量分析的方法,能显示肿瘤和正常组织之间的不同代谢,能在分子水平上反映病理情况,同时,可获得多个体素的频谱信息和代谢物的空间分布图像,是21世纪分子水平的重要检测工具之一。本文就31P磁共振频谱成像研究及应用的近况进行综述。Phosphorus is an important element in energy metabolism, and many compounds in the body contain phosphorus-31. Magnetic resonance spectroscopic imaging （MRSI） is formed through an organic combination of the space information provided by magnetic resonance imaging （MRI） and the spectroscopic information by MRS,it is a non-invasive means of compound quantitative analysis,studying the metabolism of the living body and biochemical changes, and displaying the metabolism between normal and tumorous tissues and reflect pathological change in molecular level, and could provide the spectrum in multiple voxels and the metabolites map for observing the metabolite states, it is one of the major testing tools biomedical research in the 21st century. The recent researches of phosphorus-31 magnetic resonance spectroscopic imaging and its applications were reviewed in this paper.

关 键 词：磁共振频谱学 ^31P 化学位移成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]