高盐摄入对自发性高血压大鼠循环血液中CNP及ET-1的影响  

Effects of high-salt diet on plasma concentrations of CNP and ET-1 in spontaneously hypertensive rats

作　　者：孙超峰[1] 高海燕 吕颖[1] 殷艳蓉[1] 程功[1] 

机构地区：[1]西安交通大学医学院第一附属医院心内科,西安710061 [2]陕西省辅仁医院内一科

出　　处：《陕西医学杂志》2007年第8期939-942,共4页Shaanxi Medical Journal

基　　金：美国中华医学基金会资助项目(项目编号:1-761)

摘　　要：目的:观察高盐摄入对自发性高血压大鼠(SHR)循环血液中内皮素-1(ET-1)及C型利钠肽(CNP)的影响。方法:将9周、28周、53周的雄性SHR做为3个不同的周龄组,每个周龄组再随机分为正常盐组和高盐组并进行编号,每组各7只,正常盐组给予饲料(含0.9%NaI),高盐组给予饲料(含4%NaI),共饲养3周,应用放射免疫分析技术检测各周龄组血浆中的ET-1及CNP的浓度。结果:无论是正常盐饮食还是高盐饮食,随着周龄的增加SHR的血压均升高,血液中CNP和ET-1水平也呈增龄性增加;在不同周龄组的SHR中,与正常盐组相比,高盐组SHR的血液中CNP降低,而ET-1水平升高。结论:盐负荷使SHR血液中CNP降低和ET-1升高可能是其血压增龄性升高的一个重要机制。Objective; To investigate the effects of highsalt on plasma concen-trations of CNP and ET-1 in spontaneously hypertensive rats, Methods： MaleSHR were used as experimeutal animals,and they were divided into three groups ： 9-week-old （9w）, 28-week-old （28w） and 53-week-old （53w）. Each group was divided into two sub-groups randomly： normal-salt （0. 9%NaCI） diet or high-salt （4%NaCI） diet, Each sub-groups was feeded for 3 weeks before the study. Plasma concentrations of CNP and ET-1 were measured by radioimmunoassay and were compared between normal-salt diet and high-salt diet. Results：The sistolic blood pressure increased,plasma concentrations of CNP were decreased and plasma concentrations of ET-1 increased with ageing . Compared with normal-salt diet, plasma concentrations of CNP significantly increased in all three age groups with high-salt diet（P〈0, 05） ; , compared with normalsalt diet, plasma concentrations of ET-1 increased in all three age groups with high-salt diet（P〈0.05）. Conclusion： The changes of CNP and ET-1 expression may be the base of blood pressure increase with ageing in salt-sensitive SHR.

关 键 词：高血压/病理生理学 内皮缩血管肽-1 利钠肽 C型 大鼠 

分 类 号：R544.1[医药卫生—心血管疾病]