冠心病患者血浆硫化氢含量变化  

Changes and roles of plasma hydrogen sulfide in patients with coronary heart disease

作　　者：韩文章[1] 蔡尚郎[1] 

机构地区：[1]青岛大学医学院附属医院心内科,山东青岛266003

出　　处：《实用医药杂志》2007年第5期513-514,516,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的观察冠心病患者血浆硫化氢水平变化,探讨硫化氢在冠心病发病中的临床意义。方法选取冠心病患者45例,将其分为稳定型心绞痛组、不稳定型心绞痛组和心肌梗死组,各15例;选择健康体检者15名为对照组。血浆硫化氢检测采用分光光度法检测。结果冠心病患者组血浆硫化氢水平为(37．08+10．36)μmol/L低于对照组的(50．98+6．23)μmol/L(P＜0．01);冠心病稳定型心绞痛、不稳定型心绞痛组和心肌梗死组血浆硫化氢水平分别为(47．73±3．87)μmol/L、(37．38±4．60)μmol/L、(26．87±7．56)μmol/L,各组间均有显著性差异(P＜0．01)。结论冠心病患者组血浆硫化氢水平与健康人对比相对较低,并与病变程度相关,而提示内源性硫化氢不足可能参与冠心病的病理过程。Objective To determine levels of plasma hydrogen sulfide （H2S） in patients with coronary heart disease and to investigate the roles of H2S in pathogenesis of coronary heart disease.Methods The 45 patients were randomly enrolled as study group and assigned into 3 subgroups according to stable angina pectoris （15） and unstable angina （15） and myocardial infarction （15）. Control. group conclude 15 health persons. Concentrations of plasma H2S were determined by spectrometer. Obtaimed data were processed by statistical methods which conclude student T test, F test.Results （1） The levels of H2S in patients with coronary heart disease （37.08±10.36）μmol/L were significantly reduced than that of normal controls （50.98±6.23μmol/L（P〈0.01）;（2） The concentrations of plasma H2S in 3 subgroups were 47.73±3.87μmol/L, 37.38±4.60μmol/L、26.87±7.56μmol/L, respectively. There were significant differences among the sub groups（P〈0.01）.Conclusion The concentrations of plasma H2S are lower in patients with coronary heart disease, and there is negative correlation between H：,S level and the condition of coronary heart disease. The study indicates that the pathogenesis of coronary heart disease could be involved by the short of endogenous H2S.

关 键 词：硫化氢 冠心病 病因学 

分 类 号：R446[医药卫生—诊断学] R543.3[医药卫生—临床医学]