3-(5,5-二甲基-1,3-二噁烷-2-基)-2-丁烯醛合成研究  

Study on 3-(5,5-Dimethyl-1,3-dioxan-2-yl)-2-butenal Synthesis Process

作　　者：杨泽慧[1] 周国权[1] 邵丹凤[1] 董明[1] 

机构地区：[1]宁波工程学院化工学院,浙江宁波315016

出　　处：《江西化工》2007年第2期55-59,共5页Jiangxi Chemical Industry

基　　金：宁波市自然科学基金项目(2006A610075)

摘　　要：以4-乙酰氧基-2-甲基-2-丁烯醛为原料,经醛基保护、酯交换、氧化合成3-(5,5-二甲基-1,3-二噁烷-2-基)-2-丁烯醛。首次采用氯化亚铜协同TEMPO催化氧化2-(3-羟基-1-甲基-1-丙烯基)-5,5-二噁甲基-1,3-二口恶烷,合成3-(5,5-二甲基-1,3-二噁烷—2-基)-2-丁烯醛。初步研究了催化氧化反应机理,指明了催化氧化反应研究的方向。氯化亚铜协同TEMPO催化氧化α-烯醇合成α-烯醛,对于现代类胡萝卜素类药物和其他新药开发研究具有重要意义。Synthesis process of 3 - （5,5 - dimethyl - 1,3 - dioxan - 2 - yl） - 2 - butenal was investigated. The target product was obtained by a process which involves aldehyde protection, ester exchange and catalytic oxidation from 4- acetoxy- 2- methyl- 2- butenal. Mechanism of catalytic oxidation reaction of 3 - （5,5 - dimethyl- 1,3 - dioxan- 2 - yl） - 2- buten- 1 - d with copper（ I ） chloride, 2,2,6,6- tetramethyl- 1 - piperi - dinyloxy and oxygen was studied. Technological conditions of the synthesis process were researched and the research direction of the catalytic oxidation was proposed . The Mechanism study is important for modem carotenoids and other drugs synthesis.

关 键 词：五碳醛 3-(5 5-二甲基-1 3-二噁烷-2-基)-2-丁烯醛 醛基 保护 酯交换 催化氧化 

分 类 号：TQ224.1[化学工程—有机化工]