慢性心力衰竭患者血清脂联素的浓度及临床意义  

Clinical Significance of Circulating Adiponectin Level in Chronic Congestive Heart Failure

作　　者：张凯[1] 谭茗月[1] 李安莹[1] 

机构地区：[1]中南大学湘雅二医院心内科

出　　处：《实用预防医学》2007年第5期1403-1405,共3页Practical Preventive Medicine

摘　　要：目的测定慢性心力衰竭(CHF)患者血清脂联素(APN)浓度,探讨在中国人群中血清APN对CHF患者预后的预测作用。方法采集症状基本得到控制的CHF患者血清,测定APN与N端前脑钠素(NT-proBNP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、高敏C反应蛋白(hsCRP)浓度,结合临床CHF严重程度,研究APN在预测CHF患者死亡率、再入院率的潜在价值。结果CHF患者APN水平显著升高。随CHF的严重程度(NYHA分级Ⅱ～Ⅳ)APN水平逐渐升高(P<0.05),APN与NT-proBNP正相关(r=0.48,P<0.001),与hsCRP负相关(r=-0.34,P<0.001)。血清APN水平升高伴随有死亡率的增加。结论中国CHF患者APN水平显著升高;APN可预测CHF的死亡率和复发率。Objective To determine concentrations of circulating adiponectin and the prognostic potential of adiponectin in Chinese patients with chronic congestive heart failure （CHF）. Methods Serum and clinical data were obtained for patients with clinical symptomatic controlled CHF. Serum concentrations and dependability of adiponectin, N- terminal pro- brain natriuretic peptide （NTproBNP）, tumor necrosis factor- α, interleukin- 6, and highly sensitive C reactive protein （hsCRP） were determined. The association of adiponectin with the clinical severity of CHF was sought as well as the predictive value of this adipokine on mortality and morbidity. Results Concentrations of adiponectin were significantly increased in patients with CHF. Patients with higher New York Heart Association class had significantly higher serum concentrations of adiponectin. Adiponectin serum concentrations were lower in patients with diabetes and CHF as well as in patients with ischaemic cardiomyopathy. Serum adiponectin concentration was positively associated with NT- proBNP but was negatively correlated with hsCRP. The high serum adiponectin level was associated with increased mortality and morbidity. Conclusions Adiponectin is increased in Chinese CHF patients and predicts mortality and morbidity.

关 键 词：心力衰竭 脂联素 肿瘤坏死因子-Α 白细胞介素6 预后 

分 类 号：R541.6[医药卫生—心血管疾病]