肾衰状态下肠道细菌对肌酐和尿素清除的影响  

Effects of urea and creatinine clearing with intestinal bacteria in renal failure

作　　者：蒋哲峰[1] 蒋云生[2] 林霞[2] 姚筱[2] 

机构地区：[1]中南大学湘雅二医院检验科,湖南长沙410011 [2]中南大学湘雅二医院肾病科,湖南长沙410011

出　　处：《中国医师杂志》2007年第10期1345-1347,共3页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目（30670974）

摘　　要：目的探讨肾衰状态下肠道细菌数量对肌酐及尿素清除的影响。方法SD大鼠作5/6肾切除,治疗组用肾衰康1 g·kg^-1·d^-1灌胃,正常及病理疗组灌注生理盐水,8周后留取粪便作细菌培养,采血和粪测UN、Cr浓度,统计分析各组细菌数,BUN、SCr浓度,并作相关分析。结果病理组细菌总数及大肠杆菌,腐生葡萄球菌,恶臭肠球菌、类白喉杆菌较正常对照组明显增高（P〈0.05）,治疗组较病理组细菌数明显减少（P〈0.05）。治疗组血尿素,肌酐较病理疗组明显降低（P〈0.05）,而粪尿素和肌酐明显增高（P〈0.05）。结论肾衰状态肠道细菌明显增殖,血尿素氮及血肌酐浓度与肠道细菌数量呈正相关。而与粪肌酐、粪尿素浓度相关性不大,尿素及肌酐的肠道清除不依赖肠道细菌数量。Objective To study effects of urea and creatinine clearing with intestinal bacteria in renal failure. Methods The renal subtotal ablation model was established. Groups included normal group, untreated and treated with Sheng SuaiKang group （1 g · kg^-1·d^-1 for 8 weeks）. The bacteria of the feces were cuhured and isolated. The urea and creatinine of the blood and feces were determined. The relationship between the concentration of urea and creatinine and the quantity of the intestinal bacteria was analyzed. Results The quantity of the intestinal bacteria in the untreated group was significant increased compared with that in normal group, including Escherichia coli, Saprophytic staphylococcus, Strptococcus foetidus and Diphtheroid bacillus （ P 〈 0. 05 ）. In the treated group, the bacteria quantity and the concentration of urea and creatinine were significant decreased, but increased in the feces, h had positive relationship between the quantity of intestinal bacteria and Bun or Scr, but no relation with urea and creatinine in the feces. Conclusion The quantity of intestinal bacteria is significant increased in the renal failure, which do not depend on quantity of intestinal bacteria to clear Un and Cr from intestine.

关 键 词：肾功能衰竭 肠杆菌科 肌酸酐 尿素 

分 类 号：R692[医药卫生—泌尿科学]