某些慢性疾病与原发性肝癌发病危险因素的病例对照研究  

Some chronic diseases and the risk of the occurrence of primary hepatic carcinoma:a case-control study in Hebei Province,China

作　　者：孙少华[1] 牟振云[2] 刘殿武[2] 安波[1] 刘洪杰[1] 霍荣才[1] 

机构地区：[1]河北医科大学第四医院,河北石家庄050011 [2]河北医科大学流行病与卫生统计学教研室,河北石家庄050017

出　　处：《中国健康教育》2007年第10期726-728,758,共4页Chinese Journal of Health Education

摘　　要：目的探讨某些慢性疾病与原发性肝癌(PHC)发病的关系。方法选取2006年1～7月河北省肿瘤医院、河北省人民医院、河北省第二医院就诊的新发肝癌病人进行以医院为基础的病例对照研究。对照组为与病例组年龄相差<2岁,性别相同,民族相同,职业相近、受教育程度相近、居住地相同的本地健康人群。结果单因素Logistic回归分析表明,乙型肝炎、Ⅱ型糖尿病、脂肪肝、高脂血症、酒精性肝炎是肝癌发生的危险因素,其比值比(OR)、95%CI分别为9.143(4.866-17.181)、4.861(2.236-10.568)、5.031(2.395-10.568)、2.836(1.724-4.665)和7.672(1.710-34.428)。糖尿病与乙肝对肝癌的发生有协同作用,合并糖尿病的慢性乙肝患者发生原发性肝癌的比值比为10.846,95%CI为2.475-47.526,明显高于无糖尿病的慢性乙肝患者(OR=6.940,95%CI为3.576-13.469)(P<0.05)。体重超重、肥胖,高血压、冠心病与肝癌无明显相关关系(P>0.05)。多因素Logistic回归分析表明,乙型肝炎、糖尿病、高脂血症、脂肪肝、酒精性肝炎是原发性肝癌的危险因素,其比值比、95%CI分别为13.387(6.398-28.008)、5.165(2.257-11.821)、2.946(1.698-5.111)、4.908(2.217-10.867)和8.822(1.867-41.694)。结论慢性疾病乙型肝炎、糖尿病、高脂血症、脂肪肝和酒精性肝炎是原发性肝癌的危险因素,体重超重、肥胖,高血压、冠心病与肝癌无明显相关关系。Objective To evaluate the relationship between some chronic diseases and primary hepatic carcinoma （PHC）. Methods A bespital-bassd case-control study was （conducted during January to July, 2006. 139 patients with PHC were selected as the case group, whom were treated in Hebei Provincial Tumor Hospital, Hebei General Hospital and Hebei Medical University Second Hospital, and 139 local healthy people as the control group in pair. Results By single Logistic regression analysis, hepatitis B, type 2 diabetes, fatty liver, hperlipidaemia and alooholic hepatitis were correlated positively with PHC. Each OR was 9.143, 4.861, 5.031, 2.836 and 7.672 reactively. And each 95%CI for OR was 4.866 - 17.181, 2.236 - 10.568, 2.395-10.568, 1.724-4.665 and 1.710-34.428 respectively. Type 2 diabetes and hepatitis B can promote the coocurrence of PHC. The danger degree on which chronic hepatitis B with type 2 diabetes growing into PHC was 10.846 and the 95%CI was fron 2.475 to 47.526, as well, the chronic hepatitis B widrxlt type 2 diabetes was 6.940 and 95%CI was fron 3.576 to 13.469. The former was significandy higher than the latter （ P 〈 0.05 ）. There was no correlation between PHC and overweight, fat, hypertoasion and coronary heart disease （P 〉0.05 ）. By multivariate logistic regresion analysis, we found hepatitis B, type 2 diabetes, fatty liver, hyperlipidsemia and alcoholic hepatitis could increase the risk of the occurrence of PHC. The OR and 95%CI were 13.387 （6.398 - 28.008）, 5.165 （2.257 - 11.821）, 2.946 （1.698 - 5.111）, 4.908 （2.217 - 10.867） and 8.822 （1.867-41.694） respectively. Conclusion Hepatitis B, type 2 diabetes, fatty liver, hyperlipidamia and alcoholic hepatitis were the risk factors of the coourrence of PHC. There was no correlation between PHC and overweight, fat, hypertension and coronary heart disease.

关 键 词：原发性肝癌 慢性疾病 病例对照研究 

分 类 号：R193[医药卫生—卫生事业管理]