头孢特仑新戊酯中有机溶剂残留量的毛细管GC测定  

Determination of Residual Organic Solvents in Cefteram Pivoxil by Capillary GC

作　　者：李薇[1] 李小敏[1] 

机构地区：[1]江苏先声药物研究有限公司,江苏南京210042

出　　处：《中国医药工业杂志》2007年第10期729-730,共2页Chinese Journal of Pharmaceuticals

摘　　要：建立了毛细管GC法测定头孢特仑新戊酯中乙醚、丙酮、乙酸乙酯和DMF4种有机溶剂的残留量。以甲醇为溶剂,采用HP-INNOWax毛细管柱,程序升温。各溶剂检测限分别为0.2、1、1和0.9ng,平均回收率分别为98.5%、99.6%、101.2%和100.9%。A capillary GC method with flame ionization detector was established for the determination of residual organic solvents -- ether, acetone, ethyl acetate and DMF in cefleram pivoxil. A HP-1NNOWax capillary column was used with temperature programmed control. The detection limits of the four solvents were 0.2, 1, 1 and 0.9ng, respectively. The average recoveries were 98.5 %, 99.6%, 101.2% and 100.9%, respectively.

关 键 词：头孢特仑新戊酯 有机溶剂残留量 毛细管气相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.71[化学工程—制药化工]