p57^(kip2)和cyclin D2在人脑胶质瘤中的表达和临床意义  

Expressions of p57^(kip2) and cyclin D2 proteins in human glioma and their clinical significances

作　　者：屈建强[1] 杨涛[2] 周乐[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]安康市中心医院神经外科,陕西安康725000

出　　处：《第四军医大学学报》2007年第20期1878-1880,共3页Journal of the Fourth Military Medical University

基　　金：陕西省科技计划基金资助项目(2006K09-G2(12))

摘　　要：目的:探讨p57kip2蛋白和CyclinD2蛋白在人脑胶质瘤中的表达情况及其临床意义.方法:采用免疫组织化学SP法检测p57kip2,CyclinD2在55例人脑胶质瘤和10例正常脑组织中的表达.结果:在55例胶质瘤中,p57kip2蛋白阳性率为38.2%(21/55),低于正常脑组织(80%,P<0.05).低度恶性(I～II级)与高度恶性(III～IV级)间及不同生存时间组间阳性率差异有统计学意义(P<0.05).CyclinD2蛋白阳性率为52.7%(29/55),高于正常脑组织(0%,P<0.01).脑胶质瘤不同恶性程度组间阳性率差异有统计学意义(P<0.05),不同生存时间组间差异无统计学意义(P>0.05).p57kip2蛋白的表达与CyclinD2蛋白的表达无相关(P>0.05).结论:p57kip2蛋白和CyclinD2蛋白在脑胶质瘤的发生、发展中起重要作用.且与肿瘤的分化程度,预后相关.AIM： To investigate the expressions of p57^kip2 and cyclin D2 proteins in human glioma and their clinical significances. METHODS： The expressions of p57^kip2 and cyclin D2 proteins in glioma tissues from 55 patients and normal brain tissues of 10 subjects were detected with SP immunohistochemical technique. RESULTS： The positive rate of p57^kip2 protein in glioma tissues was 38.2% （ 21/55 ） , lower than that in normal brain tissues （80%, P 〈0.05） , and it was statistically different between low- and high-grade malignant gliomas （ Ⅰ-Ⅱ vs Ⅲ-Ⅳ ） and between different length of survival time （ P 〈 0.05 ）. The positive rate of cyclin D2 protein was 52.7% （ 29/55 ）, higher than that in normal brain tissue （0% , P 〈0.01 ） , and it was significantly correlated with the grade of malignance （ P 〈 0.05 ） , but not with the two-year survival time （ P 〉 0.05 ）. The expression of P57^kip2 protein was found not related to the expression of cyclin D2 protein （P 〉 0.05 ）. CONCLUSION： Both P57^kip2 and cyclin D2 proteins play important roles in the genesis and development of human glioma. Furthermore, their expressions are correlated with the differentiation and prognosis of the glioma.

关 键 词：P57^KIP2蛋白 CyclinD2蛋白 神经胶质瘤 免疫组织化学 

分 类 号：R722.12[医药卫生—儿科]