3-乙酰基-6-苯甲酰基-N-乙基咔唑的合成  

Synthesis of 3-acetyl-6-benzoyl-N-ethylcarbazole

作　　者：冯岩[1] 陈秋容[1] 李万舜[1] 谢川[1] 

机构地区：[1]四川大学化学工程学院,四川成都610065

出　　处：《化学研究与应用》2007年第10期1162-1165,共4页Chemical Research and Application

摘　　要：The novel carbazole derivative — 3-biacetyl-6-benzoyl-N-ethylcarbazole was synthesized through alkylation and Friedel-Crafts acylation from carbazole.The structure of the target compound was characterized by 1HNMR,13CNMR,UV,IR and elemental analysis.The optimal synthetical conditions for the monoacylation was achieved by carrying out orthogonal experiments:when the mole ratio of benzoyl chloride and N-ethyl-carbazole was1.2:1,while the mole ratio of catalyst and N-ethylcarbazole was 1.2:1 at 25℃for 3h.The yield was about 94.6%.The novel carbazole derivative -3-biacetyl-6-benzoyl-N-ethylcarbazole was synthesized through alkylation and Friedel- Crafts acylation from carbazole. The structure of the target compound was characterized by IHNMR, 13CNMR, UV, IR and elemental analysis . The optimal synthetical conditions for the monoacylation was achieved by carrying out orthogonal experiments when the mole ratio of benzoyl chloride and N-ethyl-carbazole wasl. 2：1 ,while the mole ratio of catalyst and N-ethylcarbazole was 1.2：1 at 25℃ for 3h. The yield was about 94.6%.

关 键 词：N-乙基咔唑:3-乙酰基-6-苯甲酰基-N-乙基咔唑 酰化 正交实验 

分 类 号：O626.1[理学—有机化学]