铁紊乱相关疾病的研究进展  

Progress of the Study on Iron Disorder Diseases

作　　者：王莉[1] 段相林[1] 王英泽[2] 常彦忠[1] 钱忠明[1] 

机构地区：[1]河北师范大学分子神经生物学与神经药理学研究所,石家庄050016 [2]河北科技大学生物科学与工程学院,石家庄050018

出　　处：《生理科学进展》2007年第4期307-312,共6页Progress in Physiological Sciences

基　　金：河北省自然科学基金(C2006000155);河北省教育厅基金(2005130);河北科技大学科研基金(XL2006055)资助课题

摘　　要：铁作为一种必需的营养元素,在哺乳动物体内的重要作用越来越为人们所重视。动物体内存在着严格的铁代谢调节机制,以确保体内铁始终处于正常生理水平。如果铁代谢失调、体内铁缺乏或过负荷均会导致各种临床疾病。研究发现,肝脏抗菌多肽(hepcidin)很可能是一种控制小肠铁吸收及调节体内铁稳态的关键物质,是一种极为重要的铁调节激素。本文综述了铁的生理作用、铁缺乏引起的疾病(如:缺铁性贫血和儿童神经系统疾病)和铁过负荷引起的疾病(如:肝损伤、心血管疾病、帕金森病和癌症等),并对如何利用现代化技术手段在基因水平开展铁紊乱相关疾病的治疗做了展望。The important function of iron as a necessary nutrition element in mammals is more and more recognized by people. The normal physiological level of iron is ensured by the rigid regulation mechanism of iron metabolism in animals. Various clinical diseases are induced by iron disorder, like iron deficiency and iron overloading in the body. The current study showed that Hepcidin may be a key factor to control intestinal iron absorbing and regulates iron homeostasis, and may be an important regulating hormone of iron metabolism. It was summarized in this paper that the physiological functions, iron deficiency diseases, for instance iron deficiency anemia and neural diseases of children, and iron overload diseases, such as liver damage, cardiovascular diseases, Parkinson＇s disease, and cancers etc. And it was expected how to develop the therapy of iron disorder diseases in gene level use modern techniques.

关 键 词：缺铁性贫血 脑发育 铁缺乏 铁超载 肝脏抗菌多肽 

分 类 号：Q581[生物学—生物化学]