Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors  

作　　者：Jing Su Yao Liu Zhi Bing Zheng Jun Hai Xiao Hong Lu Wu Zhong Li Li Wang Shi Bo Jiang Song Li 

机构地区：[1]School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China [2]School of Pharmacy, Jilin University, Changchun 13002-1, China [3]Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China [4]Lindsley E Kimball Research Institute, the New York Blood Center, New York, NY 10021, USA

出　　处：《Chinese Chemical Letters》2007年第10期1166-1168,共3页中国化学快报（英文版）

基　　金：supported by the National Basic Research Program of China(973 project:No.2004CB518908);the National Natural Science Foundation of China(No.30472093)to SL;the 0utstanding 0verseas Chinese Scholars Fund of Chinese Academy of Sciences(No.2005-2-6)to S.J.

摘　　要：A series of novel aromatic-linked polyamine macrocyclic derivatives have been synthesized. Their structures were confirmed by MS and ^1H NMR. These compounds exhibited potent anti-HIV-1 activities.A series of novel aromatic-linked polyamine macrocyclic derivatives have been synthesized. Their structures were confirmed by MS and ^1H NMR. These compounds exhibited potent anti-HIV-1 activities.

关 键 词：HIV-1 entry inhibitors Aromatic-linked polyamine Macrocyclic derivatives SYNTHESIS 

分 类 号：TQ465.5[化学工程—制药化工]