Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography  

作　　者：Rui Juan Song Yu Fu Na Yao Yuan De Long Tian Bao Huang 

机构地区：[1]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Chinese Chemical Letters》2007年第10期1250-1252,共3页中国化学快报（英文版）

摘　　要：Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparations of DL-amino acids and DL-hydroxyl adds. The resolutions were achieved by using water containing 2.0 × 10^-4 mol/L of CuAc2 as a mobile phase, column temperature of 40 ℃, flow rate of 1.0 mL/min and detection at UV 254 nm. The elution order of D-isomer before L-isomer was observed for all DL-amino acids resolved except DL-Pro.Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparations of DL-amino acids and DL-hydroxyl adds. The resolutions were achieved by using water containing 2.0 × 10^-4 mol/L of CuAc2 as a mobile phase, column temperature of 40 ℃, flow rate of 1.0 mL/min and detection at UV 254 nm. The elution order of D-isomer before L-isomer was observed for all DL-amino acids resolved except DL-Pro.

关 键 词：Chiral stationary phase Ligand-exchange chromatography DL-Hydroxyl acid Surface grafting DL-Amino acid 

分 类 号：O6[理学—化学]