大黄虫丸对阿霉素肾硬化大鼠血栓素B_2、6-酮-前列腺素F_(1α)的影响  

Effect of Dahuangzhechongwan on Plasma TXB_2 and 6-Ket-PGF_(1α) of Rats with Adriamycin-induced Nephrosclerosis

作　　者：陈继红[1] 孙伟[1] 高坤[1] 周栋[1] 刘丽[1] 赖仁胜[1] 朱萱萱[1] 

机构地区：[1]江苏省中医院,江苏南京210029

出　　处：《中国中医药信息杂志》2007年第10期26-27,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：江苏省自然科学基金项目(BK2004162)

摘　　要：目的探讨大黄虫丸对阿霉素肾硬化大鼠尿蛋白排泄率、血脂、血浆血栓素B2(TXB2)和6-酮-前列腺素F1α(6-Keto-PGF1α)的影响。方法大鼠在单侧肾切除、分次阿霉素尾静脉注射的基础上喂饲高脂饲料,造成弥漫性系膜增生伴局灶节段性肾小球硬化动物模型。将大鼠分为假手术组、空白组、大黄虫丸组、苯那普利组,观察各组大鼠尿蛋白、血脂、血浆TXB2和6-Keto-PGF1α水平。结果大黄虫丸可明显降低大鼠尿蛋白排出量;降低血浆胆固醇含量;升高血浆6-Keto-PGF1α及降低TXB2水平。结论大黄虫丸能够祛瘀扶正,促进气血运行,通畅血脉,改善血流动力学,对阿霉素所致的肾损害具有一定的保护作用,其机制可能与其调节血栓素/前列腺素平衡有关。Objective To observe the effect of Dahuangzhechongwan on protein excretion, serum cholesterol, TXB2 and 6-keto-PGF1α in rats with adriamycin-induced nephrosclerosis, Methods The rats received twice-intravenous injections of adriamycin after one kidney was removed, and were fed with hyperlipide food to establish an animal model for diffusion mesangioproliferation following with focal segmental glomerulosclerosis. The rats were randomly divided into shame-operated group, adriamycin nephrosclerosis group, Dahuangzhechongwan group, benazepril group. Urinary protein excretion, blood fat, TXB2 and 6-keto-PGF1α were observed. Result Proteinuria extract was decreased, the plasma cholesterol was significantly lower, the level of TXB2 was cut down and 6-Ket-PGFlo was increased by Dahuangzhechongwan. Conclusion Dahuangzhechongwan has the role of simutianeous application of elimination and tonification, promoting the circulation of Qi and blood, eliminating blood stasis, improving the hemodynamics. Dahuangzhechongwan has the renal protection on rat with adriamycin-induced nephrosclerosis, the mechanism may be relate with adjusting the balance of TXB2 and 6-keto-PGF1α.

关 键 词：大黄麈虫丸 血栓素B2 6-酮-前列腺素F1Α 大鼠 

分 类 号：R285.5[医药卫生—中药学]