低氧诱导因子-1减轻组织再灌注损伤研究进展  

Hypoxia-inducible factor-1 in relieving reperfusion injury

作　　者：冯敏[1] 张培建[1] 刘新颜[1] 

机构地区：[1]扬州大学第二临床医学院普外科,225001

出　　处：《国际外科学杂志》2007年第10期688-691,共4页International Journal of Surgery

基　　金：江苏省科技厅社会发展科技项目（No.BS2004536）;江苏省扬州市科技局社会发展科技项目（No.YZ20004048）

摘　　要：低氧诱导因子-1（HIF-1）是哺乳动物细胞适应低氧的重要调节因子,是由两2个亚单位组成的复合体。近年来随着对HIF-1低氧调节的研究深入,发现了2种氧依赖酶：脯氨酸和天冬氨酸羟化酶,它们有低氧感受器样的作用,并且可对HIF-1的量进行调节。HIF-1在细胞内的增多或减少可对低氧调节基因的表达产生影响,从而改变细胞的新陈代谢。Hypoxia-inducible factor 1 （ HIF-1 ） is the most important factor involved in the mammalian cell response to hypoxia,which is a heterodimer, consisting of two subunits. Recent studies have shown that there were two oxygen-dependent enzymes：asparaginyl hydroxylase and praline hydroxylases. They worked as oxygen sensors,which could regulate the number of HIF-1. The change of HIF-1 in the quantity could impact on hypoxia-regulated genes expression, and influence cellular metabolism.

关 键 词：低氧诱导因子 缺血再灌注 羟化酶 信号传导 

分 类 号：Q[生物学]