抗幽门螺杆菌治疗腹型过敏性紫癜效果观察  

Clinical Observation of Anti-Helicobacter Pylori Therapy in Patients of Henoch Purpura

作　　者：左新年[1] 丁江华[1] 

机构地区：[1]解放军171医院内一科,江西九江332000

出　　处：《华北国防医药》2007年第5期9-10,共2页Medical Journal of Beijing Military Region

摘　　要：目的:探讨抗幽门螺杆菌(HP)治疗腹型过敏性紫癜(HSP)效果。方法:纳入60例腹型HSP患儿,应用14C尿素呼气试验检测HP,将HP(+)患儿随机分为2组:对照组18例,给予抗过敏、抗炎等常规治疗;观察组24例,在常规治疗基础上应用抗HP三联疗法。疗程均为2周,随访时间6个月。比较两组临床疗效及复发率。结果:①腹型HSPHP感染率70%;②观察组临床疗效明显高于对照组(91.67%和61.11%,P<0.05);复发率显著低于对照组(22.73%和81.82%,P<0.05)。结论:①腹型HSP与HP感染有关;②抗HP三联疗法可提高腹型HSP临床疗效,降低复发率。Objective：To discuss the effect of anti-helicobacter pylori therapy in patients with allergic purpura（ abdominal type）. Methods ：The status of Hp infection in 60 patients with allergic purpura（ abdominal type ）were detected by using the ^14C-urea breath test（^14C-UBT） test. Patients with Hp infection were divided randomly into control group （18 cases ）and observation group （24 cases ）, The patients in the observation group were given a triple-therapy consisting of omeprazole,clarithromycin,and amoxicillin for 1 week. Treatment lasted for 2 weeks with a 6-month follow up. The therapeutic efficacy and relapse rate were compared in both groups. Results：The infection rate of patients with allergic purpura was 70%. The clinical effect of the observation group was superior to that of the control group（91.67% and 61.11% ,P 〈0.05）.The relapse rate of the observation group was lower than that in the control group（22. 73% vs 81.82% ,P 〈 0. 05）. Conclusion：The infection of helicobacter pylori is closely related to allergic purpura. Anti-Helicobacter Pylori therapy can improve the efficacy and reduce the relapse rate of allergic purpura.

关 键 词：紫癜 过敏性 螺杆菌 幽门 可拉霉素 阿莫西林 奥美拉唑 

分 类 号：R554.6[医药卫生—血液循环系统疾病] R978.1[医药卫生—内科学]