1,6-二磷酸果糖治疗冠心病97例  

New Drugs and Clinical Remedies 1997 Mar; 16(2):66-68 Fructose 1,6-diphosphate for treatment of coronary disease in 97 patients

作　　者：王受益[1] 戴瑞鸿[1] 徐济民[2] 郑慧君[2] 陈曙霞[3] 陈梅芳[3] 徐惠芬[4] 赵美华[4] 荣烨之[4] 

机构地区：[1]上海医科大学附属华山医院 [2]上海第二医科大学附属第九人民医院 [3]上海第二医科大学附属仁济医院 [4]上海第二医科大学附属新华医院

出　　处：《新药与临床》1997年第2期66-68,共3页

摘　　要：目的：比较国产与进口１，６－二磷酸果糖（ＦＤＰ）对冠心病心绞痛的作用。方法：冠心病心绞痛病人１０７例，以单盲、对比法分为国产ＦＤＰ组（６６例，年龄６１±ｓ７ａ）；进口ＦＤＰ组（３１例，年龄６２±１０ａ）；对照组（２０例，年龄５９±８ａ）。国产或进口ＦＤＰ组均以１０ｇ溶于注射用水１００ｍＬ中，对照组用５％葡萄糖１００ｍＬ，３组均作静脉滴注，１０～１４ｍｉｎ内滴完，ｂｉｄ，共７ｄ。结果：国产与进口ＦＤＰ及对照组抗心绞痛症状疗效依次为８３％，８１％及２５％；心电图改善率依次为６７％，６２％及１２％；国产与进口ＦＤＰ组组间比较均Ｐ＞０．０５，２组均优于对照组（Ｐ＜０．０１）。且２组不良反应相似，均较轻微。结论：国产与进口ＦＤＰ治疗冠心病心绞痛疗效均有效。AIM: To verify the effects of domestic and imported fructose 1,6-diphosphate (FDP) on coronary heart disease (CHD). METHODS: CHD patients with angina pectoris (n=107). were divided into 3 groups: domestic FDP group (66 patients, age 61±s 7 a) and imported FDP group (31 patients, age 62±10 a) received domestic and imported, respectively, FDP 10 g dissolved in 100 mL water for injection; control group (20 patients, age 59±8 a) received 5% glucose 100 mL. all were iv drip for 10-14 min, bid×7 d. RESULTS: The effective rates of antianginal symptoms and electrocardiographic improvement had no differences between domestic FDP and imported FDP, 83%(55/66)vs 81%(25/31), 67%(34/51) vs 62%(16/26) respectively (P>0.05). However, they were superior to 25%(5/20) and 12%(2/17) in control group (all P<0.01). The main adverse reactions were mild. CONCLUSION: The efficacy of domestic and imported FDP for treatment of angina pectoris are similarly good.

关 键 词：已糖二磷酸盐类 冠状动脉疾病 冠心病 心绞痛 

分 类 号：R541.405[医药卫生—心血管疾病]