佛手瓜蒌胶囊对家兔心肌缺血损伤的保护作用  

A protective effect of to shou Gua Lou capsule on myocardial ischemia injury in rabbits

作　　者：李妍怡[1] 杜培坤[2] 

机构地区：[1]甘肃省中医院脑病科,甘肃兰州730050 [2]甘肃中医学院2005级研究生,甘肃兰州730000

出　　处：《中国中医药杂志》2007年第10期16-18,共3页

摘　　要：目的：研究佛手瓜蒌胶囊对家兔心肌缺血损伤的保护作用。方法：家兔随机分为假手术组、模型组、佛手瓜蒌胶囊小刺量组、佛手瓜蒌胶囊大刺量组及地奥心血康对照组。采用冠状动脉结扎法造成心肌缺血损伤模型，观察血清中肌酸激酶（creatine kinase，CK）、谷草转氨酶（glutamic oxaloacetic transaminase，GOT）、乳酸脱氢酶（1actate dehydrogenase，LDH）及谷丙转氨酶（glutamic pyruvate transaminase，GPT）含量的变化。结果：佛手瓜蒌胶囊小荆量组和佛手瓜蒌胶囊大剂量组与地奥心血康组比较血清中心肌酶活性的降低有显著性差异（P〈0．01）。结论：佛手瓜蒌胶囊对家免心肌缺血损伤具有保护作用。Objectiv：To observe the protective effect of FO Shou Gua Lou capsule on myocardial ischemia injury in the rabbits. Methods：The rabbits were randomly derided into the sham operation groups, model groups, Fo Shou Gua Lou capsule low-dose and high-dose treaded groups, Di Ao Xin Xue Kang capsule treaded groups. The myocardial ischemia model was prepared by coronary artery ligation. The content of creatine kinase, glutamic oxaloacetic transaminase, lactate dehydrogenase and glutamic pyruvate transaminase in the myocardial tissue were observed respectively. Results：In the Fo Shou Gua Lou capsule low-dose and high-dose treaded groups, the activities of CK. LDH, GOT , GPT in the myocardial tissue decreased significantly as compared with those of the model（P〈0. 01）.Conclusion：Fo Shou Gua Lou capsule has a protective effect of myocardial ischemia injury in the rabbits.

关 键 词：佛手瓜蒌胶囊 心肌缺血 家兔 

分 类 号：R542.2[医药卫生—心血管疾病]