“生长痛”患者骨密度与血钙、磷及碱性磷酸酶研究  

Study on bone mineral density and serum calcium,phosphorus,alkaline phosphatase of patients with growing pain

作　　者：丁文军 朱广文 王郁文 庄媛媛 李鹤 赵婷 张莹 Ding Wenjun,Zhu Guangwen,Wang yuwen,et al.（The 1st affiliated hospital of Dalian Medical University,DaLian,116011,China.）

机构地区：大连市大连医科大学附一院,辽宁大连116011

出　　处：《中国保健》2007年第4期9-10,共2页Chinese Health Care

摘　　要：目的：探讨生长痛与钙营养的关系。方法：检测生长痛患者骨密度及血钙、磷、碱性磷酸酶。结果：生长痛患者中骨密度比峰值减少13%～24%者及比峰值减少25%以上者（即骨质疏松者）分别占26%和63%,表明生长痛患者普遍存在骨钙营养不良;但血钙正常,甚至偏高,90%生长痛患者钙磷乘积大于40,90%患者碱性磷酸酶增高,提示其骨基质形成活跃及钙沉积过程正常。结论：生长痛是一种骨钙营养不良,骨矿物质含量下降引起的骨痛;其钙沉积过程不存在障碍,可能是钙营养不良,钙沉积量长期存在不足所致;骨密度检查可作为其灵敏确诊手段。Objective：To investigate the relationship between the growing pain and calcium nutrition.Methods：determine the bone mineral density （BMD） and serum calcium,phosphorus and alkaline phosphatase （ALP） of patients with growing pain.Results：26% and 63% patients with growing pain had low BMD and very lower BMD.It indicated that their bones were in a calcium malnutrition, their serum calcium were normal even higher, The mean±SD of serum calcium,product of calcium and phosphorus,ALP was（2.578±0.188）mmol/L,（50.0±6.7）（mg/dL）2,（279.9±110.9）IU,respectively.90% cases had a higher product of calcium and phosphorus,90% cases had a higher ALP.The ALP was related to osteoblasts,the higher ALP suggested that osteoblasts were in activity and more ossein was synthetised, While the product of calcium and phosphorus was above 40,the concentrations of calcium and phosphorus in bone were in an over-saturation,it was beneficial to deposition of calcium to ossein, We considered that the process of deposition of calcium should had no problem in these cases,the low BMD maybe resulted from the less amount of deposition.Conclusion：the growing pain was a bone pain,resulting from calcium malnutrition, determining BMD should be as a recommended method for making define growing pain diagnosis.

关 键 词：生长痛 骨密度 钙 营养 

分 类 号：R726.8[医药卫生—儿科;医药卫生—临床医学]