N,N-双-(苯并三(或咪)唑基甲基)羟胺与芳香酮的交换反应  

THE EXCHANGE REACTION OF N,N-BIS-(BENZOTRIAZOLYLMETHYL)HYDROXYLAMINE OR N, N- BIS- (BENZIMIDAZOLYLMETHYL)HYDROZYLAMINE WITH ARYLKETONES

作　　者：赵刚[1] 石梅[1] 徐秀娟[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《北京师范大学学报（自然科学版）》1997年第2期221-225,共5页Journal of Beijing Normal University(Natural Science)

摘　　要：在碳酸氢钠催化条件下，用一步法以苯并三唑、甲醛、盐酸羟胺为原料，合成了N，N-双-（苯并三唑基甲基）羟胺（A）．（A）或N，N-双-（苯并咪唑基甲基）羟胺（B）与苯乙酮、对位取代苯乙酮在氯化氢无水乙醇溶液中发生酮交换反应，得到5个N，N-双-（β-芳甲酰基乙基）羟胺（C），（C）与盐酸羟胺在醋酸钠溶液中反应，得到N，N-双-（β-芳甲酰基乙基）羟胺双肟（D），（D）在五氯化磷苯溶液中发生Beckmann重排，得到N，N-双-（β-芳氨基甲酰基乙基）羟胺（E）．In the presence of sodium bicarbonate, the one step reaction of benzotriazole,formaldehyde and hydroxylamme hydrochloride obtained N, N-bis - (benzotriazolylmethyl)hydroxylalmine (A) in high yield. The exchange rcaction between (A or N, N-bis- (benzimidazolylmethyl) hydrozylamine (B ) with acetophenone or p- substituted acetophenones in hydrochioride ethanolic solution, obtained five N, N- bis(β - aroylethyl) hydroxylamines (C).(C) can converted to dioximes (D) by hydroxylamine hydrochloride in sodium acetate solution.(D) treated with PCl5, in benzene solution rearrange to N, N-bis -(β-arylcarbamoylethyl)-hydroxylamines (E).

关 键 词：芳香酮 交换反应 羟胺 肟 苯并咪唑基 甲基 

分 类 号：O625.43[理学—有机化学]