硫普罗宁随机对照治疗慢性病毒性肝炎108例  

A RANDOMIZED CONTROLLED STUDY ON THE EFFICACY OF TIOPRONIN IN TREATMENT OF CHRONIC VIRAL HEPATITIS OF 108 CASES

作　　者：杨波[1,2,3] 牛正先 王萍[1,2,3] 王曙炎 买凯[1,2,3] 

机构地区：[1]河南省医学科学研究所 [2]河南省医科大学第一附属医院 [3]郑州市公路总段医务所

出　　处：《中国新药杂志》1997年第2期94-97,共4页Chinese Journal of New Drugs

摘　　要：采用随机、对照临床试验方法观察硫普罗宁片剂对１０８例慢性病毒性肝炎患者的疗效。治疗组应用硫普罗宁片剂，ｐｏ，１００ｍｇ／次，ｔｉｄ。另设对照组５４例，应用肌苷片剂２００ｍｇ／次，ｔｉｄ，和齐墩果酸片剂，ｐｏ，５０ｍｇ／次，ｑｉｄ。两组疗程均为１２周。结果显示：治疗组总有效率６３％，显著高于对照组５０％（Ｐ＜０．０５）。治疗组恶心、腹泻等不良反应亦较轻微。因此，认为硫普罗宁对慢性病毒性肝炎的疗效优于肌苷和齐墩果酸联合用药，安全性亦较好。The efficacy of tiopronin tablets in treatment of chronic viral hepatitis were conducted in 108 patients in a dose of 100 mg tid for 12 weeks.Another 54 patients in the control group were treated with inosine(200mg,tid)tablets and oleanolic acid tablets(50 mg,qid)for 12 weeks.Results showed that the total effective rate in tiopronin group is significantly higher than those in control group with mild adverse drug reactions.

关 键 词：硫普罗宁 肌苷 齐墩果酸 病毒性肝炎 药物疗法 

分 类 号：R512.605[医药卫生—内科学]