国产西替利嗪抗组胺作用的实验研究  

INHIBITORY EFFECTS OF DOMESTIC CETIRIZINE ON H 1 RECEPTOR

作　　者：黄志力[1,2] 桂常青[1,2] 宋建国[1,2] 周窑生 孙瑞元 

机构地区：[1]皖南医学院药物研究所 [2]安徽芜湖博英医药新技术有限公司

出　　处：《中国新药杂志》1997年第2期142-145,共4页Chinese Journal of New Drugs

摘　　要：采用离体豚鼠回肠试验分析ｐＡ２以及观察西替利嗪对组胺致大鼠皮肤血管通透性增高和致豚鼠休克的影响。结果表明：西替利嗪竞争性拮抗Ｈ１受体，ｐＡ２为７．１７，９５％可信限为７．１７±０．６９；西替利嗪明显对抗组胺引起的皮肤血管通透性的增高，大、中、小剂量组的作用均优于扑尔敏；其显著延长组胺静注致豚鼠呼吸加快的潜伏期，大、中剂量组的作用优于扑尔敏，小剂量组与扑尔敏相当，且可完全阻止组胺休克的发生。结果提示：西替利嗪为一强效竞争性Ｈ１受体阻断剂。The inhibitory effects of domestic cetirizine on H 1 receptor were studied in some animal models. Results showed that the capillary permeability of rats are increased and guinea pigs are effectively protected from histamine induced death by the drug.Therefore,It can be concluded that domestic cetirizine is an effective selective H 1 antagonist with negligible effects on other receptors.

关 键 词：西替利嗪 抗组胺作用 pA2 血管通透性 休克 药理 

分 类 号：R976[医药卫生—药品]