钠通道激活剂维司力农的药理与临床研究进展  

PROGRESS IN PHARMACOLOGICAL AND CLINICAL RESEARCH OF VESNARINONE——SODIUM CHANNEL ACTIVATOR

作　　者：张庆柱[1] 张均田[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所药理二室

出　　处：《中国新药杂志》1997年第1期24-29,共6页Chinese Journal of New Drugs

摘　　要：维司力农可增强心肌收缩力，延长动作电位时程（ＡＰＤ），对心率及心肌耗氧量影响很小，低剂量用于慢性充血性心衰病人。其作用主要是抑制钠通道失活，延长开放状态，Ｎａ＋内流增多，Ｎａ＋－Ｃａ２＋交换加强，使细胞内〔Ｃａ２＋〕升高。另外，维司力农尚有松弛支气管平滑肌，抑制细胞因子的生成而具有免疫抑制作用，对癌细胞的诱导分化作用以及抑制骨髓造血系统引起白血细胞减少。The pharmacological action and clinical application of vesnarinone,a sodium channel activator,were reviewed.Vesnarinone increases myocardial contractile(a positive inotropic effect)and action potential duration(APD).Its mechanism is related to inhibition of sodium channel,inactivating and increase of intracellular calicium concentration.Vesnarinone is very active on chronic congestive heart failure.Furthermore vesnarinone relaxes airway smooth muscle,inhibits cytokine production,induces cellular differentiation and apoptosis,and suppresses bone marrow progenitor cells and peripheral lymphocytes.

关 键 词：维司力农 钠通道激活剂 正性肌力效应 心力衰竭 

分 类 号：R972[医药卫生—药品]