佳代胞(PVI)治疗恶性胸腔积液Ⅲ期临床验证  

THERAPUTIC EFFECT OF PSEUDOMONAS VACCINE INJECTION(PVI) IN THE TREATMENT OF MALIGNANT PLEURAL EFFUSION

作　　者：史鹤玲[1] 徐嘉彰[1] 朱允中[1] 李敏[1] 高同军[1] 张树才[1] 胡范斌 

机构地区：[1]北京市胸部肿瘤研究所医院内科

出　　处：《中国新药杂志》1997年第1期52-54,共3页Chinese Journal of New Drugs

摘　　要：用佳代胞（ＰＶＩ）对４５例恶性胸腔积液患者进行Ⅲ期临床验证。将ＰＶＩ（２ｍｇ／ｍｌ）１～３ｍｌ注入胸腔内，变动体位，１次／周，共２次。结果：全组ＣＲ５１．１％（２３／４５），ＰＲ３１．１％（８／４５），有效率（ＣＲ＋ＰＲ）为８２．２％（３７／４５）。不良反应：恶心３７．８％，呕吐１５．６％，食欲不振６０％，发热８４．４％，胸痛８０．０％，白细胞升高（１００００～２８０００）６０％，胸水癌细胞阴转率为９２．８％（２６／２８）。ＰＶＩ治疗后Ｂ超和胸片证实均有不同程度的胸膜增厚。结果说明佳代胞的疗效明显（８２．２％），副反应不严重，可作为治疗恶性胸腔积液的有效药物。patients with malignant pleural effusion were treated with PVI by injected into pleual cavity,with a CR of 51.1%,a PR of 31.1%,and a total effective rate of 82.2%.The followig side effect were observed:nausea(37.8%),vomiting(15.6%),anorexia(60%),fever(84.4%),chest pain(80.0%),leukocytosis(60%),carcinoma cell negative(92.8%).The rsults showed that PVI is an effective drug for treatment of maligant pleural effusion with no serious side effects.

关 键 词：佳代胞 恶性胸腔积液 药物疗法 

分 类 号：R561.3[医药卫生—呼吸系统]