乙型肝炎病毒B和C基因型与干扰素a-2b治疗48周效应关系的研究  

Study on the relationship between hepatitis B virus genotypes B or C and effect of alpha-2 b interferon therapy in 48 weeks

作　　者：赵文海[1] 曾凡荣[1] 韦玉芳[1] 刘丽[1] 陈东升[1] 

机构地区：[1]连云港市第一人民医院,江苏连云港222002

出　　处：《新疆医科大学学报》2007年第9期970-971,共2页Journal of Xinjiang Medical University

基　　金：连云港市卫生局指令性科研项目(04002)

摘　　要：目的:探讨乙型肝炎病毒B和C基因型的慢性肝炎与干扰素a-2b治疗48周的疗效的关系。方法:选择HbeAg阳性的慢性乙型肝炎患者46例,用PCR核酸杂交和酶联显色技术进行HBV基因分型,观察干扰素a-2b治疗48周后的疗效。结果:慢性乙肝B基因型患者的综合应答率(41.6%)显著高于C基因型患者(24.1%)(P<0.01)。结论:慢性乙肝B基因型对干扰素a-2b的疗效明显优于C基因型,乙型肝炎病毒基因型分析用于干扰素治疗前的疗效预测具有一定的临床现实意义。Objective： The relationship between hepatitis Bvirus genotypes B or C and effect of interferon alpha-2b therapy in 48 weeks was studied. Method： Forty six patients with chronic hepatitis Bwere choicect and plasma samples of them were detected and comprared by PCR, microplate and hybridization-ELISA. Thirteen patients with genotype B and 33 patients with genotypes C received alpha-2b interferon therapy for 48 weeks. Results： The combined response rate （HbeAg loss, HBV-DNA suppreion and ALT normalization） to alpha-2b in terferon in genotypes B was significantly higher than that in genotypes C （41.6% VS 24.1%, P 〈0.01）. Conclusion： HBV genotypes may bi used to calcultate the curative effect of alpha-2b interferon and may have much clinical value.

关 键 词：乙型肝炎病毒基因型 干扰素A-2B HBEAG阳性 

分 类 号：R512.62[医药卫生—内科学] R978.7[医药卫生—临床医学]