青霉素G亚砜对—硝基苄酯的合成工艺研究  

Study on synthesis process of penicillin G sulfoxide p-nitrobenzyl ester

作　　者：栾伟丽[1] 肖鉴谋[1] 盛庆全[1] 陆平[1] 肖爱桂[1] 

机构地区：[1]南昌大学化学工程系,江西南昌330031

出　　处：《江西化工》2007年第3期88-90,共3页Jiangxi Chemical Industry

基　　金：江西省高校2005年第一批科技项目;赣财字[2005]9号

摘　　要：以青霉素G钾为原料制备青霉素G亚砜对—硝基苄酯。氧化反应的条件为:青霉素G钾与过氧乙酸的投料比(mol)为1:1.15,氧化温度<5℃,反应时间2h,青霉素G亚砜收率为93.5%;酯化反应最佳反应条件为:DMF的用量为4.28ml/1g青霉素亚砜,青霉素亚砜与对一硝基溴苄的投料比(mol)为1:1.15,反应温度为室温,反应时间为24小时,酯化收率为83.36%,反应总收率为77.92%。此方法可控制产品质量,确保操作安全简便,对工业化生产具有参考意义。Penicillin G sulfoxide p- nitrobenzyl ester was synthesized by Penicillin G. The condition of oxidation were： the molar radio of penicillin G to acetic hydroperoxide is 1 ： 1.15, the oxidization temperature is 〈 5℃ ,and the reaction time is 2h, The yield of penicillin G sulfoxide is 93.5% ; The best condition of estefification were： the amom/d of penicillin G sulfoxide to DMF was lg to 4.28ml, the molar radio of penicillin G sulfoxide to to- nitrobenzyl bromine was 1：1.15, the reaction temperature was room temperature, the reaction time was 24hr, the yield of penicillin G sulfoxide p - nitrobenzyl ester was 83.36 %, the total yield was 77.92%. This method was significant to industrial production, that was easy to control the product quality, at the same time, operating safely.

关 键 词：青霉素G钾 青霉素G亚砜对-硝基苄酯 合成 

分 类 号：TQ465[化学工程—制药化工]