芪参降脂饮对高胆固醇血症大鼠早期动脉粥样硬化的干预  

Intervention of Qishenjiangzhiyin on early artherosclerosis in hypercholesteremia rats

作　　者：李佃淳[1] 张红[2] 李玉中[3] 刘大明[4] 

机构地区：[1]连云港市第二人民医院肾内科,江苏连云港222023 [2]大连医科大学附属第二医院中医科 [3]大连医科大学附属第二医院检验科 [4]大连医科大学附属第二医院药剂科

出　　处：《中国老年学杂志》2007年第20期1968-1969,共2页Chinese Journal of Gerontology

基　　金：辽宁省教育厅科学研究计划资助(No202203250)

摘　　要：目的观察芪参降脂饮对高胆固醇血症大鼠早期动脉粥样硬化(AS)形成的影响。方法24只SD大鼠随机分为对照组,模型组和芪参降脂饮组,分别喂以普通饲料、高脂饲料和高脂饲料+芪参降脂饮;每组8只。6w后采血,测血清胆固醇(TC)和低密度脂蛋白(LDL-C)水平,观察主动脉壁组织形态学变化,用免疫组化检测主动脉血管壁细胞间黏附分子-1(ICAM-1)蛋白表达。结果芪参降脂饮组大鼠血清TC水平明显低于模型组(P<0.05),主动脉内皮损伤明显轻于模型组,中膜平滑肌排列亦较模型组整齐。模型组大鼠主动脉壁ICAM-1蛋白表达量明显高于芪参降脂饮组(P<0.01)。结论芪参降脂饮能降低血脂,抑制ICAM-1在血管壁表达和单核细胞浸润,抑制平滑肌细胞增生,防止早期AS形成。Objective To detect the intervention of Qishenjiangzhiyin on early artherosclerosis in hypercholesteremia rats, Methods Twenty-four male SD rats were randomly divided into control group（ fed with normal diet） , model group（ fed with high cholesterol diet） , and Qishenjiangzhiyin group （fed with high cholesterol diet plus Qishenjiangzhiyin）. There were eight rats in each group. Six weeks later, all the rats were killed, Serum cholesterol level were measured. The aortas were collected for histomorphology studies, The expression of intercellular adhesion molecule-1 （ ICAM-1 ） in aorta was measured by immunohistochemistry assay. Results The level of serum cholesterol of Qishenjiangzhiyin group decreased significantly compared with that of model group （ P 〈 0. 05 ）. The endothelial damage of the aortas of Qishenjiangzhiyin group was less than that of model group, The smooth muscle cells of the aortas in Qishenjiangzhiyin group were more regular than those in model group. The expression of ICAM-1 in aortas in model group was higher than that of Qishenjiangzhiyin group （P 〈 0. 01 ）, Conclusions Qishenjiangzhiyin can reduce blood fat and inhibit the expression of ICAM-1 in vessel wall,infilitration of monocytes in aorta and the proliferation of smooth muscle cell, so that it can prevent the occurrence of early artherosclerosis.

关 键 词：高胆固醇血症 动脉粥样硬化 细胞间黏附分子-1 单核细胞 平滑肌细胞 

分 类 号：R543.12[医药卫生—心血管疾病]