脂筏与T细胞信号转导  

Lipid raft mediate T cell signal transduction

作　　者：王文举[1] 李鸿钧[1] 孙茂盛[1] 

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所,昆明650118

出　　处：《生命科学》2007年第5期531-535,共5页Chinese Bulletin of Life Sciences

摘　　要：抗原提呈细胞将抗原加工处理后通过MHCⅠ/MHCⅡ类分子提呈供T细胞识别。TCR对抗原的识别引起一系列下游信号事件的发生,最终使T细胞激活,但对TCR复合物结合抗原后引起胞内区磷酸化的早期事件机制还不是很清楚。最近的研究揭示脂筏参与了这一早期信号事件的发生。脂筏是一种膜脂双层内含有的特殊微区,T细胞膜表面参与T细胞激活的各种关键信号分子都定位于脂筏。T细胞激活过程中脂筏通过聚集和重分配形成一个信号转导的平台。　Antigen is processed and presented by antigen present cell to T lymphocytes through MHC classes Ⅰ/Ⅱ molecules. The recognition of antigen by TCR stimulates TCR complex and leads to a series of downstream signaling events which activate T cell. However, the mechanism of early signaling events causing the phospho- rylation of ITAM triggered by antigen is not clear. Recent researches reveal that lipid raft may be involved in this process. Lipid raft is a special kind of detergent resistant microdomain floating on the cell plasma membrane, in which the key components of T cell activation signaling pathway locate. Lipid raft assembly into a platform for signal transduction via aggregation and redistribution during T cell activation.

关 键 词：脂筏 T细胞 信号转导 磷酸化 

分 类 号：Q73[生物学—分子生物学]