小睾丸症的激素治疗  

Hormone therapy of the small testopathy

作　　者：杨念钦[1,2] 韩银发[1,2] 陈斌[1,2] 胡凯[1,2] 黄翼然[1,2] 王益鑫[1,2] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科 [2]上海市男科学研究所,上海200001

出　　处：《中国男科学杂志》2007年第9期51-52,54,共3页Chinese Journal of Andrology

摘　　要：目的探讨小睾丸症激素治疗的临床疗效。方法回顾分析从2000年3月～2006年3月,我院诊断为小睾丸症的66例患者。按性激素检测分为:(1)高促性腺激素组即促黄体激素(LH)和促卵泡成熟激素(FSH)升高,睾酮(T)水平低下组18例;(2)低促性腺激素组即LH、FSH和T水平低下组48例。低促性腺激素组使用人绒毛膜促性腺激素(HCG),人绝经期促性腺激素(HMG);高促性腺激素组使用安特尔,两组均治疗6个月。结果低促性腺激素组患者睾酮水平均升高或达到正常水平,第二性征改善,睾丸体积由治疗前的2～4ml增大到8～11ml,患者中2例获得生育,6例患者由于使用了HCG和HMG后出现乳房发育增大、胀痛,继而改用安特尔。高促性腺激素性组使用安特尔治疗后性欲改善,睾丸体积无增大。结论小睾丸症的发病机理较为复杂,根据不同类型分别采用HCG,HMG或睾酮联合应用是有效的治疗方法之一,但要达到正常男性化,需较长时间的持续治疗。Objectives To investigate the hormone therapeutic effect of the small testopathy. Methods 66 cases of small testopathy patients treated from 2000 to 2006 have been teviewed. Results Small testopathy was treated by the HCG combined with HMG or Androgen therapy, testosterone level of all the secondary hypogonadism patients was raised Up and the male second sexual characteristics improved after treatment. The testis volume changed from 2-4ml to 8-11ml, meanwhile, the therapeutic effect was correlated with the duration of therapy. Testosterone level of the primary hypogonadism patients was also rasied,but the volume of testis was not changed. Conclusion The etiology of the small testopathy is various. The HCG combined with HMG therapy and the androgen therapy are the effective method according to the different patterns. However, in order to achieve normal androgenization, it needs long and consecutive therapy.

关 键 词：小睾丸症 激素类 治疗 

分 类 号：R588.1[医药卫生—内分泌]