2型糖尿病患者血清脂联素水平与尿微量白蛋白相关性  

Relationship between Serum Adiponectin Level and Microalbuminuria with Type 2 Diabetes

作　　者：查英[1] 刘军[1] 徐东丽[1] 盛励[1] 陈灶萍[1] 廖晓寰[2] 许群欢[3] 

机构地区：[1]复旦大学附属上海市第五人民医院内分泌科,上海200240 [2]复旦大学附属上海市第五人民医院免疫室,上海200240 [3]复旦大学附属上海市第五人民医院生化室,上海200240

出　　处：《中国临床医学》2007年第5期670-671,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨2型糖尿病患者血清脂联素(APN)水平与尿微量白蛋白之间的关系。方法:入选2型糖尿病86例,正常对照组(C)20例。检测血清脂联素(APN)、空腹血糖(FBG)、血脂、胰岛素抵抗指数(HOMR-IR)、24h尿白蛋白。根据24h尿白蛋白将糖尿病组分为糖尿病正常白蛋白尿组(NAU)60例和糖尿病伴微量白蛋白尿组(MAU)26例。结果:C组的血清APN水平最高而MAU组最低,C组与MAU组比较有显著差异(P<0.05)。Spearman相关分析显示,脂联素与24h尿白蛋白(r=-0.268,P=0.016)、FBG(r=-0.231,P=0.039)呈负相关。校正FBG后,C组APN水平仍然高于MAU组(P<0.05)。结论:2型糖尿病伴有微量白蛋白尿的患者血清APN水平下降,低脂联素血症与微量白蛋白尿密切相关。Objective：To explore the relationship between serum adiponectin（APN） level and microalbuminuria with type 2 diabetes. Methods： Eighty six patients with type 2 diabetes and twenty control subjects （C） were analyzed for serum adiponectin by EIASA. Fasting blood glucose, serum lipids, insulin resistance index （HOMR-IR） and 24h urinary albumin were measured in all subjects. The patients with type 2 diabetes were separated into normalalbuminuria（NAU） and MAU group based on 24 h urinary albumin. Results：The result showed the serum APN level was significantly higher in group C than group that of MAU （P〈0.05）. Spearman correlation analysis showed adiponectin was negatively associated with 24 h urinary albumin （r = -0. 268,P= 0. 016） and FBG（r= - 0. 231 ,P= 0. 039）. After the adjustment of FBG, the serum APN level was still higher in group C than that of group MAU（P〈0.05）. Conclusion：The result suggests that the serum adiponectin level is decreased in type 2 diabetes with MAU. Hypoadiponectinemia may be associated with MAU.

关 键 词：糖尿病 脂联素 微量白蛋白尿 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]