HBV感染者血清IL-10水平检测及临床意义  

Clinical Significance of Serum IL-10 Level in Patients with Hepatitis B

作　　者：马丽娜[1] 王麟[1] 杨柳絮[1] 赵中夫[1] 

机构地区：[1]长治医学院肝病研究所,046000

出　　处：《长治医学院学报》2007年第5期328-330,共3页Journal of Changzhi Medical College

基　　金：山西省自然科学基金(20011073)

摘　　要：目的:检测HBV感染者血清IL-10水平,探讨其在HBV持续感染及肝细胞损伤过程中的作用。方法:分离54例HBV感染者临床血清标本,其中无症状携带者21例,慢性乙肝患者33例(轻度12例,中、重度21例)。用双抗体ELISA夹心法定量检测血清IL-10水平,以10例健康献血者的血清为正常对照。结果:HBV感染者血清IL-10浓度明显高于正常对照组(P<0.05);无症状携带者及中、重度慢性乙肝患者组的明显高于轻度组(P<0.05);血清HBV-DNA高载量者明显高于低载量者(P<0.05)。结论:慢性乙肝患者血清IL-10浓度升高与HBV持续感染、HBV-DNA高载量复制及肝损伤有关;无症状携带者IL-10浓度升高可能与其诱导的免疫耐受有关。Objective：To ascertain the significance of serum IL - 10 level in patients with Hepatitis B Virus persistent infection. Methods：The serum IL- 10 level of 54 patients who had infected with Hepatitis B, including 21 HBV carriers and 33 chronic HBV patients （12 patients with mild degree,21 patients with moderate or serious degree）, were detected by ELISA.Serum IL- 10 level of 10 health people were detected as control group. Results：The serum IL- 10 level in patients with hepatitis B were significantly higher than that in the control group （ P 〈 0.05）. Both HBV carriers group and patients with moderate or serious degree group were evidently higher than mild degree group （ P 〈 0.05） ; The patients of high virus load group were obviously higher than that of low virus load group （ P 〈 0.05）. Conclusions：The serum IL- 10 level in chronic patients was related with Hepatitis B Virus persistent infection, HBV- DNA replication and the damage of liver. The higher serum IL- 10 level in HBV carriers may induce immune tolerance.

关 键 词：乙型肝炎病毒 无症状携带者 白细胞介素10 

分 类 号：R392[医药卫生—免疫学]