双歧三联活菌胶囊辅助治疗溃疡性结肠炎的疗效及机制研究  

Effect and mechanisms of adjuvant therapy for ulcerative colitis with Bifid Lriple Viable.

作　　者：李国华[1] 陈江[1] 吕农华[1] 曾晟[2] 廖旺娣[1] 徐萍[1] 周小江[1] 李宝莲[1] 王健[1] 刘丕[1] 

机构地区：[1]南昌大学第一附属医院消化科,江西南昌330006 [2]江西省人民医院高干病房,江西南昌330006

出　　处：《中国实用内科杂志》2007年第22期1776-1778,1801,共4页Chinese Journal of Practical Internal Medicine

基　　金：江西省卫生厅资助课题(20041055)

摘　　要：目的研究微生态制剂双歧三联活菌胶囊辅助治疗溃疡性结肠炎的疗效及可能机制。方法将2004年11月至2006年6月南昌大学第一附属医院消化科就诊的溃疡性结肠炎初治患者82例随机分成观察组及对照组,每组41例。对照组采用常规治疗,观察组在常规治疗的基础上加用双歧三联活菌胶囊。比较两组治疗前及治疗2个月后患者的临床症状评分、结肠黏膜炎症评分、结肠黏膜IgA的表达及外周血T淋巴细胞亚群、免疫球蛋白和补体C3、C4的差异。结果治疗2个月后两组临床症状评分、结肠黏膜炎症评分及结肠黏膜IgA均较治疗前有明显改善(P<0.01),且观察组临床症状、结肠黏膜炎症改善程度优于对照组(P<0.01),结肠黏膜IgA免疫反应阳性颗粒数高于对照组(P<0.05);外周血T淋巴细胞亚群、免疫球蛋白和补体C3、C4与治疗前比较差异均无显著性意义(P>0.05);观察组CD4+/CD8+比值较对照组显著升高(P<0.05)。结论双歧三联活菌胶囊可辅助治疗溃疡性结肠炎,其机制可能与影响结肠黏膜IgA及T淋巴细胞亚群构成有关。Objective To research the effect of Bifid Lriple Viable on validity for adjuvant treating ulcerative colitis,colon mucosa IgA and sera immunity indexes in patients with ulcerative colitis. Methods The patients with ulcerative colitis in our hospital from November 2004 to June 2006 were randomized into experiment group and control group. The patients in experiment group were treated with Bifid Lriple Viable and routine treatment, however the patients in control group received only routine treatment. The clinical symptom score, colon mucosa inflammation score, colon mucosa IgA expression,sera T lymphocyte subgroup, sera immunoglobulins and complement C3 and C4 were compared between two groups before treatment and two months after treatment. Results The clinical symptom score and colon mucosa inflammation score and colon mucosa IgA expression, sera T lymphocyte subgroup, sera immunoglobulins and complement C3 and C4 had no significant difference between two groups before treatment. Two months after treatment,the clinical symptom score and colon mucosa inflammation score descended significantly （ P 〈 0. 01 ）, especially in experiment group （ P 〈 0. 01 ）. However colon mucosa IgA expression ascended in two groups two months after treatment（ P 〈 0. 01 ）, especially in experiment group（ P 〈 0. 01 ）. Sera T lymphocyte subgroup, sera immunoglobulins and complement C3 and C4 had no sig-nificant difference in each group after treatment （ P 〉 0. 01 ）, but the ascending value of ratio of CD4^ ＋ to CD8^ ＋ T lymphocyte was more in experiment group than control group（ P 〈 0. 05 ）. Conclusion The adjuvant curative effect of Bifid Lriple Viable on ulcerative colitis is related to affecting colon mucosa IgAexpressions and constituent of sera T lymphocyte subgroup.

关 键 词：溃疡性结肠炎 双歧三联活菌胶囊 IGA 免疫球蛋白 补体 

分 类 号：R5[医药卫生—内科学]