凋亡抑制蛋白survivin和血管内皮生长因子在非小细胞肺癌中的表达及与其预后的关系  

The expression of survivin and VEGF in non-small cell lung cancer and its relationship with the prognosis

作　　者：吕喜英[1] 李青山[1] 张秀琴[2] 

机构地区：[1]承德医学院附属医院肿瘤内科,河北承德067000 [2]承德医学院附属医院检验科,河北承德067000

出　　处：《中国实用内科杂志》2007年第22期1782-1784,共3页Chinese Journal of Practical Internal Medicine

基　　金：河北省科技厅指导性课题(20042761356)

摘　　要：目的探讨凋亡抑制蛋白survivin和血管内皮生长因子(VEGF)在非小细胞肺癌(NSCLC)组织中的表达及与其预后的关系。方法应用免疫组化SP法,检测2000年1月至2003年12月承德医学院附属医院肿瘤内科收治的70例NSCLC患者(化疗组35例和非化疗组35例)肺癌组织及40例对照组患者癌旁组织中sur-vivin、VEGF的表达,比较survivin、VEGF的表达与NSCLC生存率的关系。结果survivin和VEGF在NSCLC中的阳性表达率分别为74.3%和70.0%,与对照组比较,差异均有显著性意义(P<0.01);并且二者呈正相关(P=0.032,r=0.527);化疗组中survivin、VEGF表达阳性者生存时间明显低于阴性表达者。结论survivin与VEGF在NSCLC组织中的表达呈正相关;二者联合检测对患者化疗疗效、预后的判断具有指导作用。Objective To evaluate the expression of survivin and VEGF in non-small-cell lung cancer （ NSCLC）, and discuss the relation between the prognosis of NSCLC and survivin and VEGF. Methods We had used the method of immunohistochemical techniques to test the expression level of survivin and VEGF in 35 tissue specimen who had the chemotherapy history and 35 tissues who had non-chemotherapy history of NSCLC cases, and reviewed the survival time, comparing the relationship between the expression of survivin , VEGF and the survival rate. Results The positive expression rate of survivin and VEGF was 74. 3% and 70. 0% ;survivin and VEGF had positive correlation in the expression of lung cancer tissues （P = 0. 032, r = 0. 527） ;the survival time of NSCLC person who accepted chemotherapy with positive expression of survivin and VEGF was shorter than the negative expression of survivin and VEGF. Conclusion Survivin and VEGF have positive correlation in the expression of NSCLC; the combine detection of sttrvivin and VEGF has scientific instructional action.

关 键 词：非小细胞肺癌 免疫组化 SURVIVIN VEGF 

分 类 号：R5[医药卫生—内科学]