闽产南靖巴戟天中促进骨髓基质细胞增殖成分的初步研究  

Preliminary study on the proliferation effect on bone marrow mesenchymal stem cells of constituents from radix morindae officinalis produced in Fujian province

作　　者：黄有霖[1] 郭素华[2] 赵诣[2] 

机构地区：[1]福建省药品检验所,福州350001 [2]福建中医学院药学系,中药学福建省高等学校重点实验室,福州350108

出　　处：《海峡药学》2007年第10期38-40,共3页Strait Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(项目编号:30572321)

摘　　要：目的初步研究巴戟天中促进骨髓基质细胞增殖的成分。方法采用MTT法检测从巴戟天中分离的各组分培养大鼠骨髓基质细胞(BMSCs)72h后的OD值。结果巴戟天中的蒽醌苷类成分无论极性大小,对促进BMSCs的增殖都有效,且正丁醇中极性较大的蒽醌苷类成分效果更好一些。结论巴戟天中含有能促进骨髓基质细胞增殖的成分,值得进一步深入研究。OBJECTIVE To study the constituents of radix morindae officinalis that can proliferate bone marrow mesenchymal stem cells, preliminarily. METHODS According to the MTT method, to detect the OD value after different constituents separated from radix morindae officinalis had cultured rat bone marrow mesenchymal stem cells for 72 hours. RESULTS Anthraquinone glycosides extracted from radix morindae officinalis can proliferate bone marrow mesenchymal stem ceils. And anthraquinone glycosides extracted through n -butanol have better effect. CONCLUSION Radix morindae officinalis contain constituents that can proliferate bone marrow mesenchymal stem cells and worth farther research.

关 键 词：巴戟天 骨髓基质细胞 MTT法 

分 类 号：R282[医药卫生—中药学] R931.77[医药卫生—中医学]