国产免疫抑制剂F_(904)对T细胞激活的抑制及IL-2的调节作用  

The inhibitory effects of F_(904) on T cell activation and the Up-regulatory effect of exogenolls IL-2 in the process

作　　者：姜汉英[1] 卢晓晖[1] 廖永芳[1] 余源 夏穗生[1] 江虹 程元荣 

机构地区：[1]同济医科大学附属同济医院器官移植研究所,武汉430030 [2]福建微生物研究所

出　　处：《中华器官移植杂志》1997年第2期77-79,共3页Chinese Journal of Organ Transplantation

摘　　要：通过将F904对人外用血单个核细胞（PBMC）体外作用的实验研究，对F904的免疫抑制作用及其机制进行了初步的探讨。结果表明：（1）F904能显著抑制植物血凝素（PHA）诱导的T细胞增殖反应；（2）F904对PHA激活的T细胞表面IL－2R的表达里强烈的抑制作用（P＜0．0001）；（3）增加培养细胞孔中的IL－2的含量可在一定程度上逆转由F904所致增殖抑制作用，本研究提示：降低IL－2R的表达和抑制IL－2的分泌很可能是F904免疫抑制增殖作用的基础。The in vitro effects of F904 on human single peripheral blood monocyte (PBMC) were experimentally studied to evaluate the immunosuppressive effect of F904 and its mechanism.The results showed: (1)F904 exerted marked inhibitory effect on PHA-induced T cell proliferation,(2)F904 strongly inhibited the expression of IL-2R on the surface of T cells activated by PHA (P<0, 0001 ), and (3)adding exogenous IL-2 to F904 treated lymphocytes resulted in the reversal of theantoproliferative effect to a different extent. The results suggest that the inhibitory effect of F904on T cell proliferation is most probably mediated by blocking IL-2 production as well as decreasingIL-2R expression.

关 键 词：免疫抑制剂 F_904 淋巴细胞增殖 

分 类 号：R979.5[医药卫生—药品]