壳聚糖/酸活化凹凸棒黏土复合物对双氯芬酸钠的吸附及体外释放  

Study on adsorption and in vitro release property of diclofenac sodium on the composites of chitosan and acid-activated attapulgite clay

作　　者：汪琴[1] 王文己[1] 王爱勤[1] 

机构地区：[1]中国科学院兰州化学物理研究所

出　　处：《中国生化药物杂志》2007年第5期336-339,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究壳聚糖/酸活化凹凸棒黏土(酸化凹土)复合物对双氯芬酸钠的吸附作用和体外释放性能。方法采用紫外分光度法讨论复合物中壳聚糖的体积、pH值、吸附时间对吸附率和累积释放度的影响。结果在吸附介质pH=7和吸附4 h条件下,复合物对双氯芬酸钠的吸附率和释放度可达到80%以上。结论壳聚糖/酸化凹土复合物对双氯芬酸钠具有较好的吸附和释放性能,体外释放符合Higuchi方程。Purpose To study the adsorption and in vitro release property of diclofenac sodium on the composites of chitosan and acid-activation attapulgite clays. Methods The effect of various factors, such as the volume of chitosan, pH value and adsorption time, on the adsorption ratio and cumulative dissolution of diclofenac sodium was discussed by UV spectrophotometry. Results The adsorption rate and release rate of diclofenac sodium on the composites were over 80 % under the conditions of adsorption medium pH = 7 and adsorption time 4 h. Conclusion The composites of chitosan and acid-activated attapulgite clays have good prop- erties of the adsorption and in vitro release of diclofenac sodium and in vitro release profile of diclofenac sodium from composites complies with Higuchi kinetics.

关 键 词：酸活化凹凸棒黏土 壳聚糖 双氯芬酸钠 吸附 体外释放 

分 类 号：R944[医药卫生—药剂学]