系统性红斑狼疮患者血清BAFF和IL-21的变化及意义  

Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance

作　　者：王晓非[1] 袁双龙[1] 蒋力[1] 张晓莉[1] 李舒帆[1] 郭韵[1] 吴春玲[1] 陈涓涓 

机构地区：[1]中国医科大学附属一院风湿免疫科,辽宁沈阳110001 [2]中国医科大学临床医学系,90期辽宁沈阳110001

出　　处：《细胞与分子免疫学杂志》2007年第11期1041-1042,1049,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：辽宁省教育厅基金项目资助(04D167)

摘　　要：目的:探讨系统性红斑狼疮患者血清BAFF和IL-21水平的变化意义。方法:采用酶联免疫吸附试验的方法(ELISA)对血清中两种物质进行检测。结果:系统性红斑狼疮患者血清BAFF和IL-21高于对照组;狼疮肾炎肾活检组中BAFF随病理改变加重而升高,IL-21在Ⅱ、Ⅲ型、Ⅳ型狼疮肾炎中有升高,但在Ⅳ型中改变最明显;狼疮伴干燥综合症改变组BAFF和IL-21均增加明显;应用糖皮质激素治疗1周后的患者血清BAFF和IL-21水平均呈下降趋势,但以BAFF下降最明显;系统性红斑狼疮患者血清BAFF和IL-21的变化与患者体内的主要免疫指标变化相关;在Ⅳ型狼疮肾炎患者中BAFF和IL-21的变化呈正相关。结论:系统性红斑狼疮患者血清BAFF和IL-21均增加,T、B淋巴细胞异常功能及协同作用在不同脏器的损伤和不同的病理过程中,各自发挥作用的程度不同。AIM： To investigate the changes of serum BAFF and IL-21 levels in the patients with systemic lupus erythematosus （SLE） and explore their clinical significance. METHODS： The serum levels of BAFF and IL-21 were detected by enzyme-linked immunosorbent assay （ELISA）. RESULTS： The levels of serum BAFF and IL-21 in the patients with SLE were obviously higher than those in healthy control group. The BAFF level in the group of lupus nephritis （LN） with renal biopsy increased with pathologic aggravation and the IL-21 level in Ⅱ, Ⅲ, Ⅳ LN also increased, with the most obviously change in the type IV. The levels of BAFF and IL-21 obviously increased in SLE patients with Sjogren＇s syndrome （SS）, but the levels of BAFF and IL- 21 obviously tended to decrease in the patients after glucocorticosteroid treatment for a week, with the most significant decrease in BAFF. The changes of BAFF and IL-2I were related to major immune indexes in the patients with SLE. There was positive correlation between BAFF and IL- 21 in IV LN. CONCLUSION： The levels of serum BAFF and IL-21 level are increased in the patients with SLE. The dysfunction and synergistic effect of T and B lymphocytes play different roles in the patients with different organ damage and pathoprocess respectively.

关 键 词：系统性红斑狼疮 B淋巴细胞激活因子 白介素-21 

分 类 号：R392.11[医药卫生—免疫学]