有机磷中毒以体温和出汗作为阿托品减量指征的应用价值  

Application Valuation for the Atropine Dosage Indicated by Body-temperature and Sudation in the Treatment of Acute Organophosphorus Pesticide

作　　者：梁慧霞[1] 闫再宏[1] 柴兰英[1] 郭文有[1] 张蓉[1] 陈凤慧[1] 

机构地区：[1]中国石油中心医院消化科,河北廊坊065000

出　　处：《中国误诊学杂志》2007年第27期6469-6471,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨以体温和出汗作为阿托品治疗急性有机磷中毒调整用药指征的安全性和可行性。方法:将急性有机磷中毒患者(中毒前无严重的心肺肝肾疾病)128例随机分为两组,A组以体温和出汗作为阿托品停药与减量的指征。B组以"阿托品化"作为阿托品用药过程中停药与减量指征。评价治愈率、阿托品中毒率和住院时间。结果:治愈率A组高于B组(P<0.05),阿托品中毒A组明显少于B组(P<0.01),住院时间A组少于B组(P<0.01),农药中毒反跳A组出现机会少于B组。结论:以体温和出汗作为有机磷中毒中阿托品减量指征,具有明显的安全性和可行性,可以作为治疗急性有机磷中毒的可行性方案。Objective：To investigate the security and feasibility for the treatment of acute organophosphorus pesticide （AOPP） with atropine by indication of body-temperature and sudation. Methods ：128 patients with AOPP didn＇t take severe diseases of heart ,lung,liver or kidney before poisoning. They were equally divided into two groups. The atropine dosage for Group A was indicated by body-temperature and sudation, and for Group B was indicated by atropinization. The cure rate,the atropism rate and the hospitalization days were evaluated . Results：The cure rate in Group A was higher than Group B （P〈0. 05）. The atropism rate in Group A was lower than Group B （P〈0.01）. The hospitalization days in Group A was lower than Group B （P〈0.01）. And the rebound of pesticide poisoning in Group A was lower than Group B. Conclusions：It＇s clearly safe and feasible that the atropine dosage is indicated by body-temperature and sudation. So it can be a feasible project for the treatment of AOOP.

关 键 词：有机磷化合物/中毒 中毒/药物疗法 阿托品/投药和剂量 抗副交感神经药/投药和剂量 随机对照试验[文献类型] 人类 

分 类 号：R595.5[医药卫生—内科学]