银杏总内酯注射液对实验性脑缺血及脑血流量的影响  

Effects of gingkolides injection on experimental cerebral ischemia and cerebral blood flow volume

作　　者：李元静[1] 张月玲[1] 芮菁[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《中药药理与临床》2007年第4期26-29,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察银杏总内酯注射液对实验性脑缺血及脑血流量的影响。方法:用小鼠结扎双侧颈总动脉和断头模型观察动物存活和喘息时间;大鼠结扎双侧颈总动脉,观察脑缺血大鼠脑血管通透性;大鼠脑缺血再灌试验,观察血清SOD、MDA的水平;以电磁流量计探头测定麻醉犬颈总动脉血流量,观察脑血流量和脑血管阻力的变化。结果:银杏总内酯注射液1.5mg/kg可明显延长小鼠存活和喘息时间,抑制大鼠脑血管通透性。3.0mg/kg可提高大鼠血清SOD含量、降低MDA水平。0.75mg/kg明显增加麻醉犬脑血流量,降低脑血管阻力。结论:银杏总内酯注射液对脑缺血及脑血流量具有明显改善作用。To investigate the effects of ginkgolides injection in experimental cerebral ischemia and cerebral blood flow volume. Methods： The models of ligating both common carotid arteries and dicapitative mice were used to explore the survival time and gasp duration. Li-gating both common carotid arteries and cerebral ischemia - reperfusion in rat were used to explore the cerebral capillary permeability and the content of superoxide dismutasse （ SOD）, malondiadehyde （MDA） in blood serum. Internal carotid blood flow of dog anesthetized was measured by electromagnetic flowmeter to expiore the cerebral blood flow and cerebral vascular resistance. Results： Ginkgolides injection at dose of 1.5mg/kg could significantly prolong the survival time and gasp duration, inhibited cerebral capillary permeability. At dose of 3.0mg/kg increased the content of SOD, reduced the content of MDA in blood serum. At dose of 0.75mg/kg significantly increased the cerebral blood flow and reduced the cerebral vascular resistance. Conclusion： Ginkgolides injection has improved effects on experimental cerebral ischemia and cerebral blood flow volume.

关 键 词：银杏总内酯 脑缺血 脑血管通透性 超氧化物歧化酶 脑血流量 

分 类 号：R285.5[医药卫生—中药学]