血清催乳激素与抗心磷脂抗体联合检测在子宫内膜异位症诊断中的应用  

Value of serum prolactin and anticardiolipin antibody detection in the diagnosis of endometriosis

作　　者：高宗侠[1] 凌斌[1] 吴大保[2] 姚凤球[1] 程志祥[1] 肖敏[1] 冯定庆[1] 高婷[2] 雷蕾[2] 

机构地区：[1]安徽医科大学附属省立医院,安徽省立医院安徽分子医学重点实验室,合肥230001 [2]安徽医科大学附属省立医院,安徽省立医院妇产科,合肥230001

出　　处：《中国临床保健杂志》2007年第5期449-450,共2页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金(30471805)

摘　　要：目的探讨联合检测催乳激素(PRL)和抗心磷脂抗体(ACA)在子宫内膜异位症(EMS)诊断中的应用价值。方法将90例EMS患者按美国生育学会(AFS)修正的分期法分为轻度组(Ⅰ/Ⅱ期)41例和重度组(Ⅲ/Ⅳ期)49例,以10例正常生育年龄妇女做为对照组。采用时间分辨荧光免疫法检测血清PRL,ELISA法检测血清ACA。结果(1)EMS轻度组和重度组血清PRL水平及ACA阳性率分别为(642.60±419.69)u/ml、(647.97±289.76)u/ml和63.4%、71.4%,差异无统计学意义(P>0.05),但均明显高于健康对照组(P<0.05)。(2)轻度组血清ACA阳性率34.1%,显著高于重度组和对照组(P<0.05)。结论联合检测血清PRL和ACA,有助于EMS的诊断和分期。Objective The study was to investigate the value of serum PRL and ACA detection in the diagnosis of endometrisis. Methods Serum PRL by time - resolved fluorescence assay and ACA by ELISA were detected in 41 EMS patients with stageⅠ/Ⅱ ,49 EMS patients with stage Ⅲ/Ⅳ and 10 normal women. Results （ 1 ） The positive rate and average concentrations of PRL in EMS patients with stage Ⅰ/Ⅱ and stage Ⅲ/Ⅳ were obviously higher compared with healthy control （ P 〈 0.05 ）. （ 2 ） The positive rate of ACA in EMS patients with stage Ⅰ/Ⅱ was 34.1% and was obviously higher compared with EMS patients with stage Ⅲ/Ⅳ and healthy control （P 〈 0. 05 ）. Conclusion Measurement of serum PRL and ACA may provide a valuable tool in the diagnosis and estimation of endometrisis.

关 键 词：子宫内膜异位症 催乳素 抗体 抗心脂 

分 类 号：R711.71[医药卫生—妇产科学]