电针对急性脑梗死大鼠血浆t-PA和PAI-1含量的影响  

Influences of Electro-acupuncture on the Contents of Plasma t-PA and PAI-1 in Acute Cerebral Infarction Rats

作　　者：黄伟[1] 曾庆明 吴绪平[1] 丁昀[1] 王述菊[1] 孙国杰[1] 

机构地区：[1]湖北中医学院针灸骨伤系,武汉430061 [2]洪湖市人民医院康复科,湖北洪湖433200

出　　处：《中国康复》2007年第5期300-302,共3页Chinese Journal of Rehabilitation

基　　金：湖北省教育厅科学研究计划项目(D200516006);湖北中医学院院级课题

摘　　要：目的:研究电针对急性脑梗死大鼠血浆组织型纤溶酶原激活物(t-PA)及纤溶酶原激活物抑制物-1(PAI-1)含量的影响。方法:40只SD大鼠随机分为正常组、假手术组、模型组及电针组各10只,模型组及电针组大鼠制成脑梗死模型;假手术组手术步骤同前2组,但不线栓;正常组不作任何处理。造模成功后,4组大鼠均同步喂养,电针组大鼠于造模成功后即刻给予电针百会、水沟穴,每天1次,30min。治疗5d后,4组大鼠均采用ELISA法检测血浆t-PA及PAI-1含量。结果:与正常组及假手术组比较,模型组及电针组大鼠血浆t-PA、PAI-1含量均显著升高(P<0.01),但电针组低于模型组(P<0.05,0.01)。结论:电针能显著降低急性脑梗死大鼠血浆t-PA、PAI-1含量,调节机体纤溶系统活性,改善梗死区域的血液循环,促进功能恢复。Objective： To observe the influence of electro acupuncture on the contents of plasma t-PA and PAI-1 in acute cerebral infarction rats. Methods： Forty rats were randomly divided into 4 groups, common, sham operated, model and electro acupuncture group （n--10 in each group）. The contents of plasma t-PA and PAl 1 in each group were detect ed by enzyme linked immunosorbent assay. Results： Compared with common and sham operated groups, the contents of plasma t-PA and PAl 1 in model group were significantly increased （P〈0.01）. After treatment with electro-acupunc ture, the contents of plasma t PA and PAI-1 in model group were decreased, and there was significant difference between model and electro-acupuncture group （P〈 0. 05,0. 01）. Conclusion： Electro-acupuncture can significantly decrease the contents of plasma t-PA and PAl 1 in rats with acute cerebral infarction rats, and improve the activity of fibrolysis system.

关 键 词：急性脑梗死 电针 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 

分 类 号：R245[医药卫生—针灸推拿学]