ZT胶作为门静脉栓塞材料的实验研究  

Experimental Study of ZT Glue As An Embolic Agent on Portal Vein

作　　者：庄树彤[1] 陈斌[1] 倪勇[1] 周汝明[2] 高海斌[1] 

机构地区：[1]深圳市第二人民医院普外科,深圳518035 [2]深圳市第二人民医院放射科,深圳518035

出　　处：《热带医学杂志》2007年第10期962-964,F0004,共4页Journal of Tropical Medicine

基　　金：深圳市卫生局科技资助项目(No.200104093)。

摘　　要：目的探讨ZT胶行兔选择性门静脉栓塞(SPVE)的安全性及有效性。方法新西兰白兔24只,随机分为3组,A组为ZT胶∶碘油(1∶1)混合物组,B组为ZT胶∶碘油(1∶2)混合物组,对照组C组为碘油组。对各组门静脉左支进行SPVE,术后检测门静脉压力、肝转氨酶(ALT、AST)的变化,术后30d右肝重/全肝重、全肝重/体重。结果SPVE后门静脉压力、肝转氨酶呈一过性升高;栓塞后肝左叶萎缩、纤维化,肝右叶代偿性增生肥大,右肝重/全肝重B组为69.41%,而C组为39.00%。统计学分析显示,B组栓塞效果明显优于其他组(P<0.05)。结论ZT胶∶碘油(1∶2)混合物是一种安全、有效的门静脉栓塞材料。Objective To evaluate the safety and efficacy of selective portal vein embolization （SPVE） with ZT glue in rabbit. Method Twenty-four white New Zealand rabbits were randomly divided into 3 groups. Group A received SPVE of the left branch （ZT glue ： lipiodol = 1 ： 1 ）. Group B received SPVC of the left branch （ZT glue ： lipiodol = 1 ： 2）. Group C only received lipiodol. Portal venous pressure, ALT, and AST were measured before and after SPVE. The weight of the right lobe, the whole liver, and the whole body at day-30 after SPVE were recorded and analyzed. Result A transient elevation in portal venous pressure and serum aminotransferase level was observed. Atrophy of the embolized lobes and compensatory hypertrophy of the non-embolized lobes were observed after SPVE. The weight ratios of the right lobe to the whole liver is 69.41% in group B. The best result was observed in Group B （P 〈 0.05）. Conclusion A mixture of ZT glue containing ZT-lipiedol （1 ： 2） is safe and effective in portal vein embolization.

关 键 词：ZT胶 门静脉栓塞 安全性 有效性 

分 类 号：R543.5[医药卫生—心血管疾病]