地塞米松甲状腺局部注射治疗格雷夫斯病的疗效观察  

Research on the local immunotherapy with dexamethasone used in healing Graves disease

作　　者：王旭波[1] 陆美琪[2] 石龙姣[1] 刘超[3] 阎家新[4] 

机构地区：[1]徐州医学院第二附属医院病理科 [2]徐州医学院第二附属医院内分泌科,江苏徐州221006 [3]南京医科大学第一附属医院内分泌科,江苏南京210029 [4]徐州医学院第二附属医院影像科,江苏徐州221006

出　　处：《中国实用内科杂志》2007年第21期1683-1685,共3页Chinese Journal of Practical Internal Medicine

基　　金：徐州矿务集团科研课题(2005-32WS)

摘　　要：目的评价地塞米松甲状腺局部注射治疗格雷夫斯(Graves)病的疗效。方法将徐州医学院第二附属医院2004年1月至2006年8月确诊的76例Graves病患者随机分为两组,对照组38例单纯口服他巴唑和心得安治疗,治疗组38例口服上述药物并地塞米松局部注射治疗。观察治疗前后各组临床症状、血清学变化、病理改变及副反应等,并对各组治疗前后、治疗组与对照组的各种指标进行对比分析。结果治疗组38例患者中35例显效,显效率为92.11%,且显效快、疗程短、维持时间长;对照组38例患者中28例显效,显效率为73.68%,且显效慢、疗程长、维持时间短;两组比较差异均有显著性意义(P均<0.05)。结论地塞米松局部免疫调节治疗Graves病疗效显著,疗程短,副反应小。Objective To evaluate the curative effect of local immunotherapy with dexamethasone in healing Graves disease. Methods We divided the 76 patients diagnosed as Graves disease in the Second Affiliated Hospital of Xuzhou Medical College from Jan. 2004 to Aug, 2006 into two groups randomly. The therapy group（ 38 cases）were treated with oral drug and local immunotherapy ,while the contrast group were treated with oral drug. Then we observed and analyzed the results of the two groups. Results There＇re 35 cases having exceptional curative effect such as rapid significance, short period of treatment and lasting effect in the therapy group,while only 28 cases having the less exceptional curative effect in the contrast groups. The difference was quite noticeable （P〈0.05 ）, Conclusion Local immunotherapy with dexam-ethasone used in healing Graves Disease has exceptional curative effect with short course and fewer side effects.

关 键 词：格雷夫斯病 细胞病理学 局部免疫调节治疗 地塞米松 

分 类 号：R5[医药卫生—内科学]