热碘油栓塞兔肝VX_2肿瘤的抑瘤效果  

The Anti-tumor Effect of Embolism with Heated Lipiodol for Hepatocarcinoma in V_2 Rabbits Model

作　　者：张洪新[1] 岳金胜 曹玮[1] 王执民[1] 李文献[1] 倪代会[1] 陈岚[1] 王珩[1] 

机构地区：[1]第四军医大学唐都医院介入放射科,陕西西安710038 [2]新疆乌苏市人民医院CT室

出　　处：《实用放射学杂志》2007年第10期1413-1415,共3页Journal of Practical Radiology

基　　金：全军"十一五"医学基金面上项目(编号:06M265)

摘　　要：目的评价热碘油栓塞对兔VX2肝癌的抑瘤效果。方法将VX2瘤细胞接种于30只新西兰白兔肝左叶,建立兔肝癌模型,随机分为A、B和C3组,每组10只。利用导管经肝动脉分别给生理盐水(A组)、37°C碘油(B组)和60°C碘油(C组),7d后观察各组肿瘤体积及血清AST水平,观察瘤兔的存活期。结果C组肿瘤的生长率(0.92±0.21)与A组(3.48±1.17)和B组(1.29±0.26)相比有差异(P<0.05)。C组的存活期(41.0±3.0)d与A组(31.5±3.0)d相比有差异(P<0.05)。C组血清AST水平与B组相比无差异(P>0.05),与A组相比有差异(P<0.05)。结论60°C碘油栓塞兔VX2肝癌可明显降低肿瘤生长率并延长存活期。Objective To evaluate the anti - tumour effect of embolic therapy with heated Lipiodol VX2 hepatocarcinoma rabbits. Methods VX2 carcinoma cells were surgically implanted into the left liver lober of 30 male New Zealand white rabbits, and all rabbits were divided into 3 groups （group A,B and C）at random（10 rabbits for each group）. The physiological saline,Lipiodol（37℃ ） ,Lipiodol（60℃） were respectively injected in groups A,B and C via hepatic artery to embolize the liver cancer of rabbits. 1 week later,the volume of tumour and the serum level of AST were observed. The survival period of VX2 rabbits was also observed . Results In group C , the tumour＇ s growth rate （ 0.92 ± 0.21 ） was significantly lower than that in group A （ 3.48 ±1.17 ） and B （ 1.29 ± 0.26 ） respectively （ P 〈 0.05 ）. The survival period in group C（41.0 d ±3.0 d）was significantly higher than that in group A（31.5 d ± 3.0 d） （P 〈0.05）. The serum level of AST in group C was no different in comparison with group B （P 〉 0. 05 ）,but was of significantly different compared with group A （P 〈 0. 05 ）. Conclusion Using Lipiodol （60℃ to embolize the VX2 hepatocarcinoma can obviously decrease the tumor＇s growth rate and prolong the survival period.

关 键 词：介入性热化疗 兔 VX2肿瘤 肝癌 实验性 

分 类 号：R815[医药卫生—放射医学] R-332[医药卫生—临床医学]