藻酸双酯钠及其分级产物免疫调节作用比较研究  

Comparative study on immunoregulation of sulfated propylene glycol alginate and its fractions

作　　者：林长征[1] 管华诗[1] 于广利[1] 李海花[1] 谷彩霞[1] 

机构地区：[1]海洋药物教育部重点实验室中国海洋大学医药学院,山东青岛266003

出　　处：《中国海洋药物》2007年第5期13-16,共4页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金(30130200)

摘　　要：目的探讨海洋药物藻酸双酯钠(PSS)的免疫调节作用及其构效关系。方法采用体外免疫细胞培养法检测PSS及其分级产物的免疫调节作用,根据分级产物结构差异,探讨PSS分级产物的免疫活性构效关系。结果PSS能够促进脾脏淋巴细胞的增殖,提高巨噬细胞吞噬功能,同时能抑制刀豆蛋白A(ConA)及脂多糖(LPS)促进的免疫细胞的增殖作用。结论PSS具有显著的免疫调节作用,不同的糖链长度对免疫细胞作用不同。Objective To investigate the influence of sulfated propylene glycol alginate （PSS） and its fractions on the immunoregulation. Methods The immunoregulation activity of PSS and its fractions were investigated by using immunocyte cultivation technique in vitro. The structure activity relationship was analysed on the basis of the structure studies of PSS fractions. Results The experimental results showed that PSS could improve spleen cell proliferation, enhance macrophage phagocytic function and inhibit T-cell and B-cell proliferation. Conclusion PSS possessed significant immunoregulation effect, whilst the immunocompetence comparison of PSS fractions proved that the different immunocytes had different requirements for saccharides length.

关 键 词：藻酸双酯钠 多糖 相对分子质量 免疫调节 

分 类 号：R972[医药卫生—药品] R967[医药卫生—药学]