丁香降气颗粒的提取工艺研究  

Optimal extraction of Dingxiang Jiangqi granules

作　　者：张丽红[1] 付艳[1] 张志荣[2] 王建新[1] 马淑颖[3] 朱生樑[3] 

机构地区：[1]复旦大学药学院药剂学教研室,上海200032 [2]四川大学华西药学院药剂教研室,四川成都610041 [3]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中国中药杂志》2007年第21期2252-2255,共4页China Journal of Chinese Materia Medica

摘　　要：目的:筛选并优化丁香降气颗粒的提取工艺。方法:通过药效学实验比较和确定提取工艺路线,正交设计多指标优化提取工艺条件。结果:水提法工艺提取物改善大鼠食管炎症的疗效优于其他3种工艺提取物;通过正交试验优化确定的提取条件为:加水提取3次,每次12倍量水,提取0.5 h。结论:优化得到的提取工艺合理、稳定、可行,保证了原处方的疗效。Objective： To screen and optimize the extraction of Dingxiangjiangqi granules. Method： The extraction route was screened by using pharmacodynamic experiment and the extraction conditions were optimized by orthogonal design and taking extract yield, content of naringin and tetrahydropalmatine as indexes. Result： The pharmacodynamic result showed that aqueous extract had the best effect to cure the esophagitis of rats and the optimized extraction technique was adding 12 times water, extracting 0. 5 hour for 3 times. Conclusion： The optimum extraction was simple, reasonable, stable and useful for further development.

关 键 词：丁香降气颗粒 提取工艺 药效学评价 正交设计 

分 类 号：TQ461[化学工程—制药化工]